EVL and RAD51

Data Source:
BioGRID (pull down, pull down)

		EVL	RAD51
Description		Enah/Vasp-like	RAD51 recombinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Microtubule Organizing Center PML Body Protein-containing Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	Recombinase Activity Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Single-stranded DNA Helicase Activity Enzyme Binding Identical Protein Binding DNA Polymerase Binding
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Regulation Of Protein Phosphorylation DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination Mitotic Recombination Cellular Response To DNA Damage Stimulus Reciprocal Meiotic Recombination Response To Toxic Substance Response To X-ray Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Replication Fork Processing Interstrand Cross-link Repair Strand Invasion Response To Drug Positive Regulation Of DNA Ligation Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Negative Regulation Of G0 To G1 Transition Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Glucoside Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic Recombination-dependent Replication Fork Processing
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib
Diseases
GWAS		Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)	Anxiety and stress-related disorders ( 31116379) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)
Interacting Genes		33 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP ENAH FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX	94 interacting genes: - ABL1 AGO2 ATM ATRX BARD1 BCCIP BCR BLM BRCA1 BRCA2 C1orf112 CASP3 CASP7 CCND1 CDH13 CHD3 CHEK1 CSNK2A1 CSNK2B CST6 CTCF DDB2 DMC1 DNAJA3 ENAH EP400 ERCC2 ERCC5 EVL FANCD2 FANCI FBH1 FIGNL1 HID1 HNRNPC HSP90AA1 IL24 IRS1 ITIH5 MAPK8IP3 MDC1 MMS22L MND1 MSH4 NBN NCL NELFB NXF1 PALB2 PARPBP PCSK1N PDS5B PFN1 PLK1 POLA1 RAD18 RAD51AP1 RAD51AP2 RAD51B RAD51C RAD52 RAD54B RAD54L RECQL5 RELA RFWD3 RPA1 RPA2 RPA3 SEM1 SFR1 SIRT2 ST14 SUMO1 SUMO2 SWSAP1 TFF1 TP53 TP53BP1 UBE2I UCHL3 UGDH UHRF2 UMPS USP10 VASP VIM WDR48 WRN XPO1 XRCC2 XRCC3 ZDHHC17
Entrez ID		51466	5888
HPRD ID		10942	01557
Ensembl ID		ENSG00000196405	ENSG00000051180
Uniprot IDs		A0A024R6K5 Q9UI08	Q06609
PDB IDs			1B22 1N0W 5H1B 5H1C 5JZC 5NP7 5NWL
Enriched GO Terms of Interacting Partners?
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