PLK3 and CENPU

Data Source:
BioGRID (unspecified method)

		PLK3	CENPU
Description		polo like kinase 3	centromere protein U
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Centrosome Dendrite Neuronal Cell Body	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Centriolar Satellite
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Endomitotic Cell Cycle Response To Radiation Cytoplasmic Microtubule Organization Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Mitotic G1/S Transition Checkpoint Regulation Of Cell Division Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia	Viral Process CENP-A Containing Nucleosome Assembly Chordate Embryonic Development
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Regulation of TP53 Activity through Phosphorylation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		24 interacting genes: AURKA BCL2L1 CDC25C CENPU CHEK2 CIB1 HIF1A LSM5 MAP2K1 MAPK1 MFF PLK1 POU2F1 PPM1A RAD52 RNF141 RRM2 SLX4 SNCA SNCB TNS2 TP53 TRIP13 VRK1	17 interacting genes: E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 PGRMC1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6
Entrez ID		1263	79682
HPRD ID		04222	14722
Ensembl ID		ENSG00000173846	ENSG00000151725
Uniprot IDs		Q9H4B4	Q71F23
PDB IDs		4B6L
Enriched GO Terms of Interacting Partners?
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