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PLK3 and RRM2
Data Source:
BioGRID
(two hybrid)
PLK3
RRM2
Description
polo like kinase 3
ribonucleotide reductase regulatory subunit M2
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Stack
Centrosome
Dendrite
Neuronal Cell Body
Cytosol
Molecular Function
P53 Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor
Protein Binding
Metal Ion Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Mitotic Cell Cycle
Response To Reactive Oxygen Species
Protein Phosphorylation
Apoptotic Process
Response To Osmotic Stress
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Cell Cycle Checkpoint
Endomitotic Cell Cycle
Response To Radiation
Cytoplasmic Microtubule Organization
Regulation Of Cytokinesis
Negative Regulation Of Apoptotic Process
Protein Kinase B Signaling
Mitotic G1/S Transition Checkpoint
Regulation Of Cell Division
Golgi Disassembly
Positive Regulation Of Intracellular Protein Transport
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Chaperone-mediated Autophagy
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Replication
Deoxyribonucleotide Biosynthetic Process
Nucleobase-containing Small Molecule Interconversion
Negative Regulation Of G0 To G1 Transition
Pathways
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Regulation of TP53 Activity through Phosphorylation
Interconversion of nucleotide di- and triphosphates
G1/S-Specific Transcription
Transcriptional Regulation by E2F6
Drugs
Fostamatinib
Cladribine
Imexon
Gallium nitrate
Motexafin gadolinium
GTI 2040
Diseases
GWAS
Kidney function decline traits (
25493955
)
Prostate cancer (
23535732
)
Interacting Genes
24 interacting genes:
AURKA
BCL2L1
CDC25C
CENPU
CHEK2
CIB1
HIF1A
LSM5
MAP2K1
MAPK1
MFF
PLK1
POU2F1
PPM1A
RAD52
RNF141
RRM2
SLX4
SNCA
SNCB
TNS2
TP53
TRIP13
VRK1
9 interacting genes:
CDH1
CDK1
DNM1L
KAT5
PLK3
RRM1
RRM2B
SDCBP
TP53
Entrez ID
1263
6241
HPRD ID
04222
01587
Ensembl ID
ENSG00000173846
ENSG00000171848
Uniprot IDs
Q9H4B4
P31350
PDB IDs
4B6L
2UW2
3OLJ
3VPM
3VPN
3VPO
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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