CENPU and TUBB2B

Data Source:
BioGRID (two hybrid)

		CENPU	TUBB2B
Description		centromere protein U	tubulin beta 2B class IIb
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Centriolar Satellite	Nucleus Cytoplasm Microtubule Microtubule Cytoskeleton Schaffer Collateral - CA1 Synapse
	Molecular Function	Protein Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Heterodimerization Activity
	Biological Process	Viral Process CENP-A Containing Nucleosome Assembly Chordate Embryonic Development	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Microtubule-based Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Axon Guidance Embryonic Brain Development
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs			CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS
Interacting Genes		17 interacting genes: E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 PGRMC1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6	10 interacting genes: ANXA7 BID C8orf33 CACNA1A CDKN1A CENPU CSNK2B HDAC6 RGS2 RPL35
Entrez ID		79682	347733
HPRD ID		14722	14707
Ensembl ID		ENSG00000151725	ENSG00000137285
Uniprot IDs		Q71F23	A0A384MEE3 Q9BVA1
PDB IDs			6E7C
Enriched GO Terms of Interacting Partners?
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