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PLK3 and RAD52
Data Source:
BioGRID
(two hybrid)
PLK3
RAD52
Description
polo like kinase 3
RAD52 homolog, DNA repair protein
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Stack
Centrosome
Dendrite
Neuronal Cell Body
Nucleus
Nucleoplasm
Protein-containing Complex
Protein-DNA Complex
Molecular Function
P53 Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
DNA Binding
Single-stranded DNA Binding
Protein Binding
Identical Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Mitotic Cell Cycle
Response To Reactive Oxygen Species
Protein Phosphorylation
Apoptotic Process
Response To Osmotic Stress
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Cell Cycle Checkpoint
Endomitotic Cell Cycle
Response To Radiation
Cytoplasmic Microtubule Organization
Regulation Of Cytokinesis
Negative Regulation Of Apoptotic Process
Protein Kinase B Signaling
Mitotic G1/S Transition Checkpoint
Regulation Of Cell Division
Golgi Disassembly
Positive Regulation Of Intracellular Protein Transport
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Chaperone-mediated Autophagy
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia
Double-strand Break Repair Via Homologous Recombination
DNA Recombinase Assembly
Double-strand Break Repair
DNA Recombination
Mitotic Recombination
Cellular Response To DNA Damage Stimulus
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Cellular Response To Oxidative Stress
Double-strand Break Repair Via Single-strand Annealing
Regulation Of Nucleotide-excision Repair
Pathways
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Regulation of TP53 Activity through Phosphorylation
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
Drugs
Fostamatinib
Diseases
GWAS
Blood protein levels (
29875488
)
Body mass index (
26426971
)
Eosinophil percentage of granulocytes (
27863252
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Immature fraction of reticulocytes (
32888494
)
Lung cancer (
22899653
)
Neutrophil percentage of granulocytes (
27863252
)
Small cell lung carcinoma (
28604730
)
Systolic blood pressure (
30224653
30578418
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
24 interacting genes:
AURKA
BCL2L1
CDC25C
CENPU
CHEK2
CIB1
HIF1A
LSM5
MAP2K1
MAPK1
MFF
PLK1
POU2F1
PPM1A
RAD52
RNF141
RRM2
SLX4
SNCA
SNCB
TNS2
TP53
TRIP13
VRK1
25 interacting genes:
ABL1
AURKB
DCP1A
ERCC1
ERCC2
ERCC3
ERCC4
KPNA3
KPNA5
MCM2
MCM3
MEOX1
MEOX2
NFYC
PAX5
PLK3
RAD51
RDM1
RPA1
RPA2
SEM1
SUMO1
TTK
UBE2I
WRN
Entrez ID
1263
5893
HPRD ID
04222
11855
Ensembl ID
ENSG00000173846
ENSG00000002016
Uniprot IDs
Q9H4B4
B7Z2G8
B7Z5Q6
F5GX32
P43351
Q5DR82
PDB IDs
4B6L
1H2I
1KN0
5JRB
5XRZ
5XS0
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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