CENPU and NDUFS2

Data Source:
BioGRID (two hybrid)

		CENPU	NDUFS2
Description		centromere protein U	NADH:ubiquinone oxidoreductase core subunit S2
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Centriolar Satellite	Nucleoplasm Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix
	Molecular Function	Protein Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Quinone Binding NAD Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Viral Process CENP-A Containing Nucleosome Assembly Chordate Embryonic Development	Mitochondrial Electron Transport, NADH To Ubiquinone Response To Oxidative Stress Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31361310 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Granulocyte percentage of myeloid white cells ( 27863252)
Interacting Genes		17 interacting genes: E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 PGRMC1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6	5 interacting genes: APP CENPU EGR2 HMOX2 TNFRSF14
Entrez ID		79682	4720
HPRD ID		14722	04285
Ensembl ID		ENSG00000151725	ENSG00000158864
Uniprot IDs		Q71F23	B7Z792 O75306
PDB IDs			5XTB 5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?