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PLK3 and PPM1A
Data Source:
BioGRID
(two hybrid)
PLK3
PPM1A
Description
polo like kinase 3
protein phosphatase, Mg2+/Mn2+ dependent 1A
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Stack
Centrosome
Dendrite
Neuronal Cell Body
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Membrane
Molecular Function
P53 Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Magnesium Ion Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Manganese Ion Binding
Calmodulin-dependent Protein Phosphatase Activity
R-SMAD Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Mitotic Cell Cycle
Response To Reactive Oxygen Species
Protein Phosphorylation
Apoptotic Process
Response To Osmotic Stress
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Cell Cycle Checkpoint
Endomitotic Cell Cycle
Response To Radiation
Cytoplasmic Microtubule Organization
Regulation Of Cytokinesis
Negative Regulation Of Apoptotic Process
Protein Kinase B Signaling
Mitotic G1/S Transition Checkpoint
Regulation Of Cell Division
Golgi Disassembly
Positive Regulation Of Intracellular Protein Transport
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Chaperone-mediated Autophagy
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia
Negative Regulation Of Transcription By RNA Polymerase II
Protein Dephosphorylation
N-terminal Protein Myristoylation
Cell Cycle Arrest
Negative Regulation Of SMAD Protein Complex Assembly
Dephosphorylation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Peptidyl-threonine Dephosphorylation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Protein Export From Nucleus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of NIK/NF-kappaB Signaling
Pathways
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Regulation of TP53 Activity through Phosphorylation
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Energy dependent regulation of mTOR by LKB1-AMPK
Drugs
Fostamatinib
Diseases
GWAS
Allergic rhinitis (
22036096
)
Blond vs. brown/black hair color (
30531825
)
Chronotype (
30696823
)
Diastolic blood pressure (
30224653
)
Hair color (
29662168
)
Hip circumference adjusted for BMI (
25673412
)
Menarche (age at onset) (
27182965
)
Refractive error (
32231278
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
24 interacting genes:
AURKA
BCL2L1
CDC25C
CENPU
CHEK2
CIB1
HIF1A
LSM5
MAP2K1
MAPK1
MFF
PLK1
POU2F1
PPM1A
RAD52
RNF141
RRM2
SLX4
SNCA
SNCB
TNS2
TP53
TRIP13
VRK1
37 interacting genes:
AATK
AKT1
ALK
CACNA1A
CACNA1B
CACNA1C
CDC42BPA
CDC42BPB
CTNNB1
DVL1
DVL2
DVL3
EEF2
EGFR
ERBB2
ERBB3
ERBB4
FGFR2
GRM3
HSPB1
IGF1R
KDR
LMTK2
MSN
NR4A1
PAK1
PAK2
PIK3R1
PLK3
PRKAA1
PRKCA
PRKCD
PTK7
ROR2
RPLP0
SMAD2
SMAD3
Entrez ID
1263
5494
HPRD ID
04222
16199
Ensembl ID
ENSG00000173846
ENSG00000100614
Uniprot IDs
Q9H4B4
A0A024R6A5
B2R8E4
P35813
PDB IDs
4B6L
1A6Q
3FXJ
3FXK
3FXL
3FXM
3FXO
4RA2
4RAF
4RAG
6B67
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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