CENPU and E2F6

Data Source:
BioGRID (two hybrid)

		CENPU	E2F6
Description		centromere protein U	E2F transcription factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Centriolar Satellite	Chromatin Nucleus Nucleoplasm MLL1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity
	Biological Process	Viral Process CENP-A Containing Nucleosome Assembly Chordate Embryonic Development	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS			Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Sudden cardiac arrest ( 21658281)
Interacting Genes		17 interacting genes: E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 PGRMC1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6	27 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11
Entrez ID		79682	1876
HPRD ID		14722	04251
Ensembl ID		ENSG00000151725	ENSG00000169016
Uniprot IDs		Q71F23	A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5
PDB IDs
Enriched GO Terms of Interacting Partners?
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