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PLK3 and CIB1
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(two hybrid, in vivo, in vitro)
PLK3
CIB1
Description
polo like kinase 3
calcium and integrin binding 1
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Stack
Centrosome
Dendrite
Neuronal Cell Body
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Plasma Membrane
Membrane
Apical Plasma Membrane
Lamellipodium
Dendrite
Growth Cone
Vesicle
Filopodium Tip
Ruffle Membrane
Sarcolemma
Neuron Projection
Neuronal Cell Body
Perikaryon
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Cell Periphery
Molecular Function
P53 Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Calcium Ion Binding
Protein Binding
Protein C-terminus Binding
Calcium-dependent Protein Kinase Inhibitor Activity
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Small GTPase Binding
Protein-membrane Adaptor Activity
Ion Channel Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Mitotic Cell Cycle
Response To Reactive Oxygen Species
Protein Phosphorylation
Apoptotic Process
Response To Osmotic Stress
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Cell Cycle Checkpoint
Endomitotic Cell Cycle
Response To Radiation
Cytoplasmic Microtubule Organization
Regulation Of Cytokinesis
Negative Regulation Of Apoptotic Process
Protein Kinase B Signaling
Mitotic G1/S Transition Checkpoint
Regulation Of Cell Division
Golgi Disassembly
Positive Regulation Of Intracellular Protein Transport
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Chaperone-mediated Autophagy
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia
Angiogenesis
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell-matrix Adhesion
Response To Ischemia
Double-strand Break Repair
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Microtubule Depolymerization
Endomitotic Cell Cycle
Cell Adhesion
Spermatid Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Neuron Projection Development
Platelet Formation
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Cytoplasmic Microtubule Organization
Positive Regulation Of Cell Adhesion Mediated By Integrin
Thrombopoietin-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Negative Regulation Of Megakaryocyte Differentiation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cell Division
Regulation Of Cell Division
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Protein Targeting To Membrane
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Protein Localization To Plasma Membrane
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of Male Germ Cell Proliferation
Pathways
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Regulation of TP53 Activity through Phosphorylation
Drugs
Fostamatinib
Calcium citrate
Calcium Phosphate
Calcium phosphate dihydrate
Diseases
GWAS
Interacting Genes
24 interacting genes:
AURKA
BCL2L1
CDC25C
CENPU
CHEK2
CIB1
HIF1A
LSM5
MAP2K1
MAPK1
MFF
PLK1
POU2F1
PPM1A
RAD52
RNF141
RRM2
SLX4
SNCA
SNCB
TNS2
TP53
TRIP13
VRK1
37 interacting genes:
AURKB
CALCB
CD27
CDK4
CEACAM6
EIF4G1
ELAPOR1
EXOSC10
FEZ1
FUCA1
GLIS3
IFI6
ITGA2B
LSS
NBR1
NCK2
NME4
NRIP1
ONECUT3
PAX3
PAX7
PLK2
PLK3
PRKDC
PSEN1
PSEN2
PTK2
RAC3
SCAF1
SSX7
TERT
TMEM95
TSGA10IP
UBR5
WAS
ZBTB49
ZDHHC17
Entrez ID
1263
10519
HPRD ID
04222
03800
Ensembl ID
ENSG00000173846
ENSG00000185043
Uniprot IDs
Q9H4B4
A0A140VK09
Q99828
PDB IDs
4B6L
1DGU
1DGV
1XO5
1Y1A
2L4H
2L4I
2LM5
6OCX
6OD0
Enriched GO Terms of Interacting Partners
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