Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
ACKR2 and CCL5
Data Source:
BioGRID
(pull down)
HPRD
(in vivo)
ACKR2
CCL5
Description
atypical chemokine receptor 2
C-C motif chemokine ligand 5
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Early Endosome
Cytosol
Actin Filament
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Nuclear Membrane
Intracellular Membrane-bounded Organelle
Recycling Endosome
Extracellular Region
Extracellular Space
Molecular Function
Chemokine Receptor Activity
Scavenger Receptor Activity
Protein Binding
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Phosphatidylinositol Phospholipase C Activity
Protein Kinase Activity
Protein Binding
Chemokine Activity
Phospholipase Activator Activity
Receptor Signaling Protein Tyrosine Kinase Activator Activity
CCR1 Chemokine Receptor Binding
CCR4 Chemokine Receptor Binding
CCR5 Chemokine Receptor Binding
Chemoattractant Activity
Chemokine Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Self-association
Chemokine Receptor Antagonist Activity
CCR Chemokine Receptor Binding
Biological Process
Endocytosis
Chemotaxis
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Multicellular Organism Development
Calcium-mediated Signaling
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
MAPK Cascade
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Regulation Of Chronic Inflammatory Response
Protein Phosphorylation
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Leukocyte Cell-cell Adhesion
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Response To Virus
Response To Toxic Substance
Positive Regulation Of Activation Of Janus Kinase Activity
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of T Cell Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Cellular Biosynthetic Process
Activation Of Phospholipase D Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of T Cell Proliferation
Neutrophil Activation
Positive Regulation Of Phosphorylation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Positive Regulation Of Translational Initiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Eosinophil Chemotaxis
Macrophage Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Insulin Secretion
Regulation Of T Cell Activation
Positive Chemotaxis
Positive Regulation Of Calcium Ion Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Chemokine-mediated Signaling Pathway
Negative Regulation Of Chemokine-mediated Signaling Pathway
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of T Cell Apoptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotaxis
Regulation Of Neuron Death
Positive Regulation Of T Cell Migration
Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways
Chemokine receptors bind chemokines
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
Heparin Disaccharide I-S
Heparin Disaccharide Iii-S
Diseases
GWAS
Blood protein levels (
29875488
28240269
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Eotaxin levels (
27989323
)
Granulocyte count (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Monocyte chemoattractant protein-1 levels (
27989323
)
Monocyte count (
29403010
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neonatal cytokine/chemokine levels (fetal genetic effect) (
30134952
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Sum basophil neutrophil counts (
27863252
)
Sum eosinophil basophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
White blood cell count (
32888494
27863252
)
Blood protein levels (
30072576
28240269
)
Interacting Genes
24 interacting genes:
APP
CCL11
CCL13
CCL14
CCL19
CCL2
CCL21
CCL25
CCL27
CCL28
CCL3
CCL3L3
CCL4
CCL5
CCL7
CCL8
CREB3
EFNA5
GJA8
MS4A1
NIPAL4
SACM1L
SLC13A4
TMEM167B
55 interacting genes:
ACKR1
ACKR2
ACKR4
APC
BAG4
BCAR3
CCL11
CCL13
CCL16
CCL17
CCL2
CCL20
CCL21
CCL24
CCL25
CCL26
CCL27
CCL28
CCR1
CCR3
CCR4
CCR5
CHEK2
CXCL10
CXCL11
CXCL12
CXCL14
CXCL17
CXCL2
CXCL6
CXCL8
CXCL9
DPP4
EDC4
FZR1
GRB2
IGFBP7
KRAS
PALB2
PF4
PHB
PIGR
PPBP
PTPN1
RANGAP1
RELA
SDC1
SDC4
SLC2A5
TGFB1
TRIP6
VCAN
WT1
XCL1
XCL2
Entrez ID
1238
6352
HPRD ID
09095
01751
Ensembl ID
ENSG00000144648
ENSG00000271503
Uniprot IDs
A1LP82
O00590
A0A494C1Q1
D0EI67
P13501
PDB IDs
1B3A
1EQT
1HRJ
1RTN
1RTO
1U4L
1U4M
1U4P
1U4R
2L9H
2VXW
5CMD
5COY
5DNF
5L2U
5UIW
6AEZ
6C6D
6FGP
6LOG
6STK
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?