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WNK1 and MT-ATP8
Data Source:
BioGRID
(two hybrid)
WNK1
MT-ATP8
Description
WNK lysine deficient protein kinase 1
ATP synthase F0 subunit 8
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Membrane
Mitochondrial Proton-transporting ATP Synthase Complex, Coupling Factor F(o)
Mitochondrial Inner Membrane
Mitochondrial Proton-transporting ATP Synthase Complex
Integral Component Of Membrane
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Chloride Channel Inhibitor Activity
Potassium Channel Inhibitor Activity
Protein Kinase Binding
Phosphatase Binding
Protein Kinase Activator Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Proton-transporting ATP Synthase Activity, Rotational Mechanism
Biological Process
Regulation Of Sodium Ion Transport
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Ion Transport
Signal Transduction
Negative Regulation Of Sodium Ion Transport
Positive Regulation Of T Cell Chemotaxis
Negative Regulation Of Phosphatase Activity
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Activation Of Protein Kinase Activity
Negative Regulation Of Cell-cell Adhesion Mediated By Integrin
Negative Regulation Of Heterotypic Cell-cell Adhesion
Negative Regulation Of GTPase Activity
Intracellular Signal Transduction
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Neuron Development
Regulation Of Cellular Process
Ion Homeostasis
T Cell Receptor Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Lymphocyte Migration Into Lymph Node
Negative Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Potassium Ion Import Across Plasma Membrane
Regulation Of Cation Transmembrane Transport
Cellular Response To Chemokine
Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
ATP Biosynthetic Process
Cristae Formation
Mitochondrial ATP Synthesis Coupled Proton Transport
Pathways
Stimuli-sensing channels
Formation of ATP by chemiosmotic coupling
Cristae formation
Drugs
Diseases
Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS
Adult body size (
32376654
)
Blood protein levels (
29875488
)
Body mass index (
25673413
29273807
)
Body size at age 10 (
32376654
)
Eosinophil counts (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Lung cancer (
28604730
)
Lung cancer in ever smokers (
28604730
)
Manganese levels (
26025379
)
Monocyte percentage of white cells (
32888494
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Squamous cell lung carcinoma (
28604730
)
Stroke (
19369658
)
Interacting Genes
36 interacting genes:
ADRB2
AKT1
ARAF
ATXN1
BAG3
CLTC
COPS5
CSDE1
E2F3
FHL3
FLNC
GLIS2
KLHL2
KLHL3
MAP2K1
MAP3K2
MAP3K3
MT-ATP8
PFKP
PRKAR1A
PRKAR1B
PVR
RANBP9
SLC9A1
SYT2
TNRC6A
TSC22D1
TULP3
UBE2I
UPF2
WNK2
YWHAE
YWHAG
YWHAZ
ZNF106
ZYX
4 interacting genes:
GRB2
PACSIN1
RAPGEF2
WNK1
Entrez ID
65125
4509
HPRD ID
05570
Ensembl ID
ENSG00000060237
ENSG00000228253
Uniprot IDs
A5D8Z4
F5GWT4
Q9H4A3
A0A1X7RCP4
P03928
U5YV54
PDB IDs
4PWN
5TF9
5WDY
5WE8
6FBK
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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