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WNK1 and RANBP9
Data Source:
BioGRID
(two hybrid)
WNK1
RANBP9
Description
WNK lysine deficient protein kinase 1
RAN binding protein 9
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Membrane
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Associated Complex
Plasma Membrane
Nuclear Body
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Chloride Channel Inhibitor Activity
Potassium Channel Inhibitor Activity
Protein Kinase Binding
Phosphatase Binding
Protein Kinase Activator Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Binding
Enzyme Binding
Biological Process
Regulation Of Sodium Ion Transport
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Ion Transport
Signal Transduction
Negative Regulation Of Sodium Ion Transport
Positive Regulation Of T Cell Chemotaxis
Negative Regulation Of Phosphatase Activity
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Activation Of Protein Kinase Activity
Negative Regulation Of Cell-cell Adhesion Mediated By Integrin
Negative Regulation Of Heterotypic Cell-cell Adhesion
Negative Regulation Of GTPase Activity
Intracellular Signal Transduction
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Neuron Development
Regulation Of Cellular Process
Ion Homeostasis
T Cell Receptor Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Lymphocyte Migration Into Lymph Node
Negative Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Potassium Ion Import Across Plasma Membrane
Regulation Of Cation Transmembrane Transport
Cellular Response To Chemokine
Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
MAPK Cascade
Cytoskeleton Organization
Microtubule Nucleation
Cell Surface Receptor Signaling Pathway
Axon Guidance
Protein-containing Complex Assembly
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways
Stimuli-sensing channels
L1CAM interactions
RAF/MAP kinase cascade
MET activates RAS signaling
Drugs
Diseases
Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS
Adult body size (
32376654
)
Blood protein levels (
29875488
)
Body mass index (
25673413
29273807
)
Body size at age 10 (
32376654
)
Eosinophil counts (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Lung cancer (
28604730
)
Lung cancer in ever smokers (
28604730
)
Manganese levels (
26025379
)
Monocyte percentage of white cells (
32888494
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Squamous cell lung carcinoma (
28604730
)
Stroke (
19369658
)
Breast cancer (
29059683
23535729
)
Interacting Genes
36 interacting genes:
ADRB2
AKT1
ARAF
ATXN1
BAG3
CLTC
COPS5
CSDE1
E2F3
FHL3
FLNC
GLIS2
KLHL2
KLHL3
MAP2K1
MAP3K2
MAP3K3
MT-ATP8
PFKP
PRKAR1A
PRKAR1B
PVR
RANBP9
SLC9A1
SYT2
TNRC6A
TSC22D1
TULP3
UBE2I
UPF2
WNK2
YWHAE
YWHAG
YWHAZ
ZNF106
ZYX
56 interacting genes:
ADAP1
ADAP2
APC
AR
ATM
AXL
BACE1
BRCA1
CACNA1G
CALB1
CBS
CCND1
CDK11B
CLEC7A
DDX4
DISC1
DYRK1B
ENTPD1
ESR1
EXOC2
FMR1
HIPK2
HMBS
HNF4G
ITGAL
ITGB2
L1CAM
LMNA
MAPK6
MET
MPHOSPH8
NCOA6
NCOR2
NSRP1
PPARD
PPARG
PPP1CA
PRKACA
RAF1
RAN
S100A7
SMAD2
SMAD3
SMAD9
SOS1
SPOP
SPP1
TFRC
THRA
THRB
TP53
TP73
UCHL1
USP11
WNK1
YPEL5
Entrez ID
65125
10048
HPRD ID
05570
04835
Ensembl ID
ENSG00000060237
ENSG00000010017
Uniprot IDs
A5D8Z4
F5GWT4
Q9H4A3
A0A024QZW3
Q96S59
PDB IDs
4PWN
5TF9
5WDY
5WE8
6FBK
5JI7
5JI9
5JIU
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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