OCRL and PHETA1

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		OCRL	PHETA1
Description		OCRL inositol polyphosphate-5-phosphatase	PH domain containing endocytic trafficking adaptor 1
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosome Early Endosome Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Phagocytic Vesicle Membrane Early Endosome Membrane	Early Endosome Trans-Golgi Network Cytosol Clathrin-coated Vesicle Recycling Endosome
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity	Protein Binding Protein Homodimerization Activity
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Regulation Of Small GTPase Mediated Signal Transduction Cilium Assembly Membrane Organization	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Rho GTPase cycle Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases		Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis Lowe syndrome; Oculocerebrorenal Dystrophy (OCRL)
GWAS
Interacting Genes		14 interacting genes: CDC42 CLTC GOLGA5 GRB2 LHX3 PHETA1 PHETA2 RAB14 RAB1A RAB31 RAB5A RAB6A RAB8A RAC1	15 interacting genes: ABI2 C11orf68 CYSRT1 FCHO1 GRB2 HOXA1 KRTAP1-3 KRTAP13-2 KRTAP6-3 NCK2 OCRL OIP5 PHETA2 PLEKHJ1 SORBS3
Entrez ID		4952	144717
HPRD ID		02395	08127
Ensembl ID		ENSG00000122126	ENSG00000198324
Uniprot IDs		A0A2X0TVZ9 Q01968 Q504W7	Q8N4B1
PDB IDs		2KIE 2QV2 3QBT 3QIS 4CMN	3QIS
Enriched GO Terms of Interacting Partners?
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