OCRL and GOLGA5

Data Source:
HPRD (two hybrid)

		OCRL	GOLGA5
Description		OCRL inositol polyphosphate-5-phosphatase	golgin A5
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosome Early Endosome Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Phagocytic Vesicle Membrane Early Endosome Membrane	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Integral Component Of Membrane Transport Vesicle Golgi Cisterna
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity	Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Regulation Of Small GTPase Mediated Signal Transduction Cilium Assembly Membrane Organization	Retrograde Transport, Vesicle Recycling Within Golgi Golgi Organization Golgi Vesicle Transport
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Rho GTPase cycle Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	Intra-Golgi traffic
Drugs
Diseases		Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis Lowe syndrome; Oculocerebrorenal Dystrophy (OCRL)
GWAS			Body mass index ( 26426971)
Interacting Genes		14 interacting genes: CDC42 CLTC GOLGA5 GRB2 LHX3 PHETA1 PHETA2 RAB14 RAB1A RAB31 RAB5A RAB6A RAB8A RAC1	4 interacting genes: CUX1 ITSN1 OCRL RAB1A
Entrez ID		4952	9950
HPRD ID		02395	06079
Ensembl ID		ENSG00000122126	ENSG00000066455
Uniprot IDs		A0A2X0TVZ9 Q01968 Q504W7	Q8TBA6
PDB IDs		2KIE 2QV2 3QBT 3QIS 4CMN
Enriched GO Terms of Interacting Partners?
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