CLK1 and LMNA

Data Source:
BioGRID (enzymatic study)

		CLK1	LMNA
Description		CDC like kinase 1	lamin A/C
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nuclear Envelope Nuclear Lamina Nucleoplasm Cytosol Intermediate Filament Nuclear Matrix Nuclear Body Nuclear Speck Nuclear Membrane Site Of Double-strand Break
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Binding
	Biological Process	Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation	Mitotic Nuclear Envelope Reassembly Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Protein Localization To Nucleus IRE1-mediated Unfolded Protein Response Cellular Response To Hypoxia Positive Regulation Of Cell Aging Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress DNA Double-strand Break Attachment To Nuclear Envelope
Pathways			XBP1(S) activates chaperone genes Signaling by BRAF and RAF fusions
Drugs		Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
Diseases			Restrictive dermopathy Emery-Dreifuss muscular dystrophy Dilated cardiomyopathy (DCM) Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Mandibuloacral dysplasia Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Limb-girdle muscular dystrophy (LGMD) Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy Hutchinson-Gilford progeria syndrome
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)	Birth weight ( 31043758) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Ischemic heart disease in rheumatoid arthritis ( 30251476) Lung cancer in ever smokers ( 28604730) Neutrophil count ( 32888494) Ovarian cancer ( 30557369) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		166 interacting genes: ABCA13 ACOX2 ANKFY1 ARHGEF12 ARPC4 ASL ASXL3 ATP10A ATP4A BCLAF1 C1orf94 CDCP1 CDH23 CDK12 CELSR3 CENPE CEP95 CFAP20DC CFAP251 CKAP5 CLASRP CLK2 COCH CRNKL1 CTNND2 CUL3 CWC27 CYP46A1 DBR1 DENND4A DNAJC13 DNAJC24 DOCK9 DPYD DSC2 DVL3 ECE1 ELP6 ENO1 ERFE FAM189A1 FAT1 FBF1 FHIP2B GEMIN5 GOLM1 GRM6 GSDMB H2BC12 HADH HIVEP1 HNMT HNRNPA0 HNRNPA1 HNRNPA3 HSP90AB2P HSPBP1 HTATSF1 ICE1 IMPDH2 IP6K1 ITGA5 KATNA1 KHDRBS1 KIF14 KIF23 KRT8 KRTAP10-6 KRTAP10-7 LINS1 LMNA LNX1 LUC7L3 MAP3K21 MAP7 MBP MFHAS1 MFSD10 MICU3 MKRN2 MTBP MTCL1 MYOM1 NCL NCOR1 NF1 NPM1 NUP153 PATZ1 PDE9A PHF3 PHLDB2 PIAS4 PIP4K2B PKD1L1 PLAAT5 PLXDC2 PPFIBP2 PPHLN1 PPIG PPP1CB PRDX5 PRKDC PRMT5 PRPF38A PRPF4 PRPF4B PTPN1 PTPN22 RAD21L1 RAPH1 RASL12 RBBP6 RBM15 RBM39 RBMX REV1 RLF RPL5 RPS4Y1 RPUSD3 SAFB SAMD9L SCARA3 SERPINI2 SF3B1 SFMBT2 SH2B2 SHROOM1 SLC35D3 SLFN5 SPEN SPTBN4 SRPK1 SRPK2 SRRM1 SRRM2 SRRM4 SRSF1 SRSF10 SRSF3 SRSF5 SRSF6 SRSF7 SSBP3 STIP1 STK31 SVOP TEX11 THRAP3 THY1 TJP2 TLN2 TMPO TMPRSS2 TNIP2 TP53RK TRA2B UBL5 UNC13B VWA7 YTHDC1 YWHAG ZC3H13 ZMYND10 ZNF148	381 interacting genes: ABCA9 ACOT7 ACTB ADAM33 ADGRE2 ADGRG7 AGTRAP AIG1 AKTIP ALG3 ALG8 ALOX12 ALOX12B ANKRD20A5P ANXA6 AOC3 APOA2 APOD APOL2 AQP1 AQP10 AQP3 ARHGEF16 ARL6IP1 ASGR1 ATP6V0C BCL2L2 BNIP2 BNIP3 BNIP3L BRICD5 BTN2A2 BYSL C11orf24 C1QTNF1 C20orf141 C3orf52 C4orf3 C5 CACNG1 CASP1 CASP6 CCDC120 CCNG1 CD52 CD72 CD81 CDK1 CDS2 CENPP CETN3 CFHR5 CHST1 CLCA4 CLCN7 CLDN10 CLDND2 CLEC1A CLEC4A CLK1 CLN6 CMTM3 CMTM5 CMTM7 CNIH3 COL8A2 COX14 CREB3 CRY2 CSGALNACT2 CTSA CWF19L2 CXCL14 CXCL16 CYB561 CYB561D2 CYB5B CYBC1 CYBRD1 DBNDD2 DDX24 DDX43 DEFB127 DERL1 DERL2 DNAJC30 DUS3L DUSP13 EDDM3B EGF EIF3G ELOA EMD ENTPD3 ERG28 F2RL1 FA2H FAIM FAM161A FAM3C FAM9B FATE1 FAXDC2 FBXO7 FCER1A FCER1G FDFT1 FETUB FLNA FOS FXYD3 FXYD6 GALNT2 GIN1 GJB2 GJB5 GOLGA2P10 GOLT1B GOSR2 GPR108 GPR25 GRM2 GZMA GZMB HACD1 HCK HMOX1 HMOX2 IFFO1 IFIT2 IGFBP5 INSIG2 ITGAM ITM2B IZUMO2 JAGN1 KASH5 KAT5 KCNK1 KCNK13 KIF12 KPNA6 KRT6A KRTAP10-3 KRTAP10-7 LAMB1 LAT LCP2 LEPROTL1 LHFPL5 LIMS2 LINC01587 LMBR1 LMNB1 LMNB2 LPAR3 LRP10 LVRN MAL MALL MAPRE2 MARVELD1 MATR3 MCM5 MEOX1 MFAP1 MFSD5 MGLL MGST3 MIP MLIP MMD2 MORF4L1 MRPS26 MS4A1 MTHFD2 MUTYH MYADM NAB2 NALCN NARF NAT8 NEU1 NINJ2 NIPAL3 NKG7 NOD2 NTAQ1 ORMDL1 ORMDL3 OSBPL8 OSTCP1 OSTF1 PAQR5 PARPBP PCBP1 PCGF2 PCNA PELI1 PERM1 PIAS2 PIK3R2 PKD2 PLLP PLP1 PLP2 PLPP4 PMP22 PNKP PNLIPRP1 PRELID3A PRKCA PRNP PTPN9 PYGM RABAC1 RANBP9 RB1 RBBP4 REEP6 RGS18 RHAG RMDN2 RNF123 RPRM RTN1 RTN3 RTN4 RUSF1 SACM1L SBDS SCARA3 SCARB2 SEC22A SEC22B SELENOK SENP2 SERP1 SERP2 SERPINE1 SFT2D2 SFTPC SGMS2 SH3RF2 SIAH1 SLC13A3 SLC1A1 SLC2A5 SLC30A2 SLC30A3 SLC30A8 SLC35A1 SLC35A4 SLC35B2 SLC35B4 SLC38A7 SLC41A2 SLC7A1 SLN SLU7 SMAD1 SMAD3 SMCO4 SMIM11A SMURF1 SMURF2 SNORC SPANXC SPANXD SPG21 SPN SREBF1 SRPK2 STAC STAC2 STARD3 STX12 STX3 STX4 STX5 STX6 STX7 STX8 SUMO2 SUMO4 SVIL SYCE1 SYNE1 SYNGR1 SYPL1 SYT6 TAP1 TCEA2 TCEANC TDO2 TFRC THBD TM4SF20 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM14C TMEM199 TMEM201 TMEM203 TMEM208 TMEM218 TMEM222 TMEM230 TMEM234 TMEM243 TMEM267 TMEM41A TMEM42 TMEM43 TMEM51 TMEM54 TMEM60 TMEM65 TMEM74 TMEM86A TMPO TMPRSS4 TNF TNFRSF10C TNFSF12 TNMD TOR1A TOR1AIP1 TRAM1L1 TRIM26 TRIM39 TSGA10 TSNARE1 TSPAN2 TSPAN33 TSPAN7 UBE2I UBE2Q1 UBQLNL UCHL5 UNC13D UNC45A UNC50 UPK1B URB2 USE1 USP2 USP20 VAMP1 VAMP2 VAMP3 VAMP5 VKORC1 VMP1 VSTM1 VTI1B WFDC2 YIPF1 YIPF6 YWHAQ ZC2HC1C ZDHHC15 ZDHHC24 ZMYM6 ZNF138 ZNF239 ZNF25 ZNF3 ZNF439 ZNF440 ZNF490 ZNF564 ZNF569 ZNF69 ZSCAN12
Entrez ID		1195	4000
HPRD ID		09058	01035
Ensembl ID		ENSG00000013441	ENSG00000160789
Uniprot IDs		P49759	A0A384MQX1 P02545 Q5TCI8
PDB IDs		1Z57 2VAG 5J1V 5J1W 5X8I 6FT8 6FT9 6FYO 6G33 6I5H 6I5I 6I5K 6I5L 6KHD 6Q8K 6Q8P 6QTY 6R3D 6R6E 6R6X 6R8J 6RAA 6TW2 6YTA 6YTD 6YTE 6YTG 6YTI 6Z4Z 6Z50 6ZLN	1IFR 1IVT 1X8Y 2XV5 2YPT 3GEF 3V4Q 3V4W 3V5B 6GHD 6JLB 6RPR 6SNZ 6YF5
Enriched GO Terms of Interacting Partners?
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