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CLK1 and UNC13B
Data Source:
BioGRID
(enzymatic study)
CLK1
UNC13B
Description
CDC like kinase 1
unc-13 homolog B
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Synaptic Vesicle Membrane
Neuromuscular Junction
Presynaptic Membrane
Terminal Bouton
Presynaptic Active Zone
Presynaptic Active Zone Cytoplasmic Component
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Phospholipid Binding
Syntaxin-1 Binding
Diacylglycerol Binding
GTP-dependent Protein Binding
Small GTPase Binding
Biological Process
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Regulation Of RNA Splicing
Protein Autophosphorylation
Chemical Synaptic Transmission
Neurotransmitter Secretion
Neuromuscular Junction Development
Positive Regulation Of Synaptic Vesicle Priming
Glutamate Secretion
Synaptic Vesicle Docking
Synaptic Vesicle Priming
Synaptic Vesicle Maturation
Synaptic Transmission, Glutamatergic
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Positive Regulation Of Protein Secretion
Acrosomal Vesicle Exocytosis
Dense Core Granule Priming
Cellular Response To Glucose Stimulus
Positive Regulation Of Inhibitory Postsynaptic Potential
Neuronal Dense Core Vesicle Exocytosis
Presynaptic Dense Core Vesicle Exocytosis
Pathways
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Drugs
Debromohymenialdisine
CHGN111
ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
Fostamatinib
Diseases
GWAS
Breast cancer (
27117709
)
Breast cancer (estrogen-receptor negative) (
27117709
)
Triptolide cytotoxicity (
26121980
)
Parkinson's disease (
21812969
)
Interacting Genes
166 interacting genes:
ABCA13
ACOX2
ANKFY1
ARHGEF12
ARPC4
ASL
ASXL3
ATP10A
ATP4A
BCLAF1
C1orf94
CDCP1
CDH23
CDK12
CELSR3
CENPE
CEP95
CFAP20DC
CFAP251
CKAP5
CLASRP
CLK2
COCH
CRNKL1
CTNND2
CUL3
CWC27
CYP46A1
DBR1
DENND4A
DNAJC13
DNAJC24
DOCK9
DPYD
DSC2
DVL3
ECE1
ELP6
ENO1
ERFE
FAM189A1
FAT1
FBF1
FHIP2B
GEMIN5
GOLM1
GRM6
GSDMB
H2BC12
HADH
HIVEP1
HNMT
HNRNPA0
HNRNPA1
HNRNPA3
HSP90AB2P
HSPBP1
HTATSF1
ICE1
IMPDH2
IP6K1
ITGA5
KATNA1
KHDRBS1
KIF14
KIF23
KRT8
KRTAP10-6
KRTAP10-7
LINS1
LMNA
LNX1
LUC7L3
MAP3K21
MAP7
MBP
MFHAS1
MFSD10
MICU3
MKRN2
MTBP
MTCL1
MYOM1
NCL
NCOR1
NF1
NPM1
NUP153
PATZ1
PDE9A
PHF3
PHLDB2
PIAS4
PIP4K2B
PKD1L1
PLAAT5
PLXDC2
PPFIBP2
PPHLN1
PPIG
PPP1CB
PRDX5
PRKDC
PRMT5
PRPF38A
PRPF4
PRPF4B
PTPN1
PTPN22
RAD21L1
RAPH1
RASL12
RBBP6
RBM15
RBM39
RBMX
REV1
RLF
RPL5
RPS4Y1
RPUSD3
SAFB
SAMD9L
SCARA3
SERPINI2
SF3B1
SFMBT2
SH2B2
SHROOM1
SLC35D3
SLFN5
SPEN
SPTBN4
SRPK1
SRPK2
SRRM1
SRRM2
SRRM4
SRSF1
SRSF10
SRSF3
SRSF5
SRSF6
SRSF7
SSBP3
STIP1
STK31
SVOP
TEX11
THRAP3
THY1
TJP2
TLN2
TMPO
TMPRSS2
TNIP2
TP53RK
TRA2B
UBL5
UNC13B
VWA7
YTHDC1
YWHAG
ZC3H13
ZMYND10
ZNF148
11 interacting genes:
CLK1
DOC2A
DOC2B
PDCL2
RIMS1
RPH3AL
SPTBN2
STX1A
STX1B
STX2
TOE1
Entrez ID
1195
10497
HPRD ID
09058
05785
Ensembl ID
ENSG00000013441
ENSG00000198722
Uniprot IDs
P49759
O14795
Q4LE73
PDB IDs
1Z57
2VAG
5J1V
5J1W
5X8I
6FT8
6FT9
6FYO
6G33
6I5H
6I5I
6I5K
6I5L
6KHD
6Q8K
6Q8P
6QTY
6R3D
6R6E
6R6X
6R8J
6RAA
6TW2
6YTA
6YTD
6YTE
6YTG
6YTI
6Z4Z
6Z50
6ZLN
Enriched GO Terms of Interacting Partners
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