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LZTS1 and CDC23
Data Source:
BioGRID
(two hybrid)
LZTS1
CDC23
Description
leucine zipper tumor suppressor 1
cell division cycle 23
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Postsynaptic Density
Apical Plasma Membrane
Dendritic Spine
Dendritic Shaft
Cell Body
Postsynaptic Membrane
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Microtubule Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Biological Process
Negative Regulation Of Macroautophagy
Mitotic Cell Cycle Phase Transition
Regulation Of Synaptic Plasticity
Regulation Of Dendrite Morphogenesis
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Mitotic Metaphase Plate Congression
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Regulation Of Exit From Mitosis
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Circulating myeloperoxidase levels (serum) (
23620142
)
Dental caries (
23064961
23259602
)
Influenza A (H1N1) infection (
26379185
)
Major depressive disorder (broad) (
20038947
)
Preeclampsia (
23551011
)
Rheumatoid arthritis (
30891314
)
Severe influenza A (H1N1) infection (
26379185
)
Susceptibility to persistent hepatitis B virus infection (
27244555
)
Autism spectrum disorder or schizophrenia (
28540026
)
Resting heart rate (
27798624
)
Interacting Genes
100 interacting genes:
AGTR1
AMOT
AP1M1
BYSL
CARD9
CCDC102B
CCDC120
CCDC13
CCDC187
CCDC57
CCHCR1
CDC23
CDC25C
CDC37
CDC7
CDK1
CEP83
CKS1B
COG2
COPB1
CWF19L2
DDX6
EEF1G
ELOA
ENKD1
EXOC8
FAM161A
FAM161B
FAM50B
FAM71F1
FAM81B
FAM90A1
GAS8
GOLGA1
GPKOW
HMGB2
IDO2
KANK2
KAT5
KAZN
KDM1A
KIF9
KIFC3
LENG1
LMNB2
LMO1
LMO2
LMO3
LMO4
LNX1
LSM2
MAPK9
MCRS1
METTL21A
MFAP1
MID2
NEK6
NTAQ1
PIBF1
PICK1
PLEKHA7
POLR1C
POLR3C
PPP1R18
PRKAB2
PRPF18
PRPF3
PSMA1
PSPC1
QARS1
RABIF
RHPN1
RSPH14
RUNX1T1
SCNM1
SGF29
SOGA1
SPDYC
SUFU
SYT17
SYT6
SYTL4
TBC1D1
TBC1D7
TCEA2
TSGA10
TSGA10IP
TTC9C
TXLNA
TXLNB
TXNDC9
UBASH3A
ZGPAT
ZMYND19
ZNF250
ZNF3
ZNF35
ZNF417
ZNF572
ZNF587
81 interacting genes:
ANAPC10
ANAPC13
ANKRD11
APOL1
ATRIP
BCAS3
BEGAIN
BHLHB9
BYSL
C21orf91
CBY2
CCDC125
CCDC24
CCDC33
CDC16
CDT1
CEP44
CERCAM
COIL
CRACR2A
CRTC2
CTBP1
CYB5R2
DCLK1
DEPDC1B
DISC1
DLX6-AS1
EIF5A2
FAM9B
FBXO5
FOXN1
GORASP2
GTPBP8
HEMK1
IHO1
INCA1
INO80E
INPP5J
KCTD6
KDM1A
KRT36
LHX3
LZTS1
LZTS2
MAGED1
MAPK3
NAB2
NRBF2
NUP54
OPTN
PFKFB4
PIH1D2
PNMA5
POU6F2
PROSER3
PRPF31
PRR22
RAC1
RAD54B
RBM15B
RBP3
RBPMS
RSL24D1
RUNX1T1
SIAH1
SLC52A2
SMARCB1
SMUG1
SORBS3
SOX5
SPAG8
SSX2IP
STX2
SUV39H1
TEPSIN
TNIP1
TRIM27
TSC22D4
UBE2S
USP54
ZMAT1
Entrez ID
11178
8697
HPRD ID
05945
07221
Ensembl ID
ENSG00000061337
ENSG00000094880
Uniprot IDs
Q9Y250
Q9UJX2
PDB IDs
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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