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CDC23 and SORBS3
Data Source:
BioGRID
(two hybrid)
CDC23
SORBS3
Description
cell division cycle 23
sorbin and SH3 domain containing 3
Image
GO Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Cytosol
Nucleus
Cytosol
Cytoskeleton
Focal Adhesion
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Transcription Factor Binding
Vinculin Binding
Biological Process
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Mitotic Metaphase Plate Congression
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Regulation Of Exit From Mitosis
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Transcription By RNA Polymerase II
Muscle Contraction
Actin Filament Organization
Cell Adhesion
Cell-substrate Adhesion
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cytoskeleton Organization
Positive Regulation Of Stress Fiber Assembly
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Smooth Muscle Contraction
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Resting heart rate (
27798624
)
Diastolic blood pressure (
30224653
)
HIV-1 viral setpoint (
20205591
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Parkinson's disease (
28892059
)
Interacting Genes
81 interacting genes:
ANAPC10
ANAPC13
ANKRD11
APOL1
ATRIP
BCAS3
BEGAIN
BHLHB9
BYSL
C21orf91
CBY2
CCDC125
CCDC24
CCDC33
CDC16
CDT1
CEP44
CERCAM
COIL
CRACR2A
CRTC2
CTBP1
CYB5R2
DCLK1
DEPDC1B
DISC1
DLX6-AS1
EIF5A2
FAM9B
FBXO5
FOXN1
GORASP2
GTPBP8
HEMK1
IHO1
INCA1
INO80E
INPP5J
KCTD6
KDM1A
KRT36
LHX3
LZTS1
LZTS2
MAGED1
MAPK3
NAB2
NRBF2
NUP54
OPTN
PFKFB4
PIH1D2
PNMA5
POU6F2
PROSER3
PRPF31
PRR22
RAC1
RAD54B
RBM15B
RBP3
RBPMS
RSL24D1
RUNX1T1
SIAH1
SLC52A2
SMARCB1
SMUG1
SORBS3
SOX5
SPAG8
SSX2IP
STX2
SUV39H1
TEPSIN
TNIP1
TRIM27
TSC22D4
UBE2S
USP54
ZMAT1
133 interacting genes:
ABI2
ABL1
ADAM15
ADAMTSL4
ADAT3
AKIRIN2
AKT2
ANKS1A
ARNT2
C1orf109
CATSPER1
CBFA2T2
CBLB
CCDC102B
CCDC120
CCDC187
CCDC57
CCDC6
CCHCR1
CCNH
CCNL1
CDC23
CDKN2C
CFAP206
CHERP
COG4
CPEB2
CPNE1
CPNE2
CPNE8
CPSF7
CRACR2A
DDX17
DDX6
DIP2A
DLG5
DMRTB1
DVL2
DVL3
EFHC1
EFS
EIF3H
ENKD1
FAM214B
FAM53C
FASLG
FBXL19
FLOT1
FNDC11
GAS8
GEM
GLRA1
GPANK1
GPKOW
GYS1
HGS
HNRNPF
HNRNPK
HNRNPUL1
IMP3
INPPL1
INSC
IQUB
KANK2
KIAA0408
KIAA1217
KIFC3
MAPK1
MAPK3
MKRN3
MYO15B
NAB2
NAF1
NCK1
NCKIPSD
NEK6
NFKBID
NHSL2
NOTCH3
NRBP1
OIP5
OSGIN1
PAK2
PAK5
PHETA1
PHF1
PIBF1
PLEKHN1
PLOD3
PNMA5
POLE2
POLR1C
PPFIA3
PPIL6
PPP1R18
QARS1
RAD51D
RBMX
RIN1
ROPN1
RUNX1T1
SAFB2
SAXO1
SCNM1
SETD5
SH2D4A
SOCS7
SPG21
SRCIN1
SYNPO2L
TBC1D22B
TCEANC
TEAD4
TEPSIN
TNS2
TRIM23
TRIM27
TRIM41
TSGA10
TSGA10IP
TXLNA
USP2
VARS2
VCL
VPS37B
VPS37C
WIPF2
ZBED1
ZBTB25
ZBTB7B
ZC2HC1C
ZC4H2
ZNF414
Entrez ID
8697
10174
HPRD ID
07221
11535
Ensembl ID
ENSG00000094880
ENSG00000120896
Uniprot IDs
Q9UJX2
O60504
PDB IDs
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
2CT3
2DLM
2NWM
2YUP
Enriched GO Terms of Interacting Partners
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