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CDC23 and TSC22D4
Data Source:
BioGRID
(two hybrid, two hybrid)
HPRD
(two hybrid)
CDC23
TSC22D4
Description
cell division cycle 23
TSC22 domain family member 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Cytosol
Nucleus
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Protein Binding
Biological Process
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Mitotic Metaphase Plate Congression
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Regulation Of Exit From Mitosis
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Transcription By RNA Polymerase II
Response To Osmotic Stress
Negative Regulation Of Transcription, DNA-templated
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Resting heart rate (
27798624
)
Brain morphology (MOSTest) (
32665545
)
Platelet count (
27863252
)
Refractive error (
32231278
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
81 interacting genes:
ANAPC10
ANAPC13
ANKRD11
APOL1
ATRIP
BCAS3
BEGAIN
BHLHB9
BYSL
C21orf91
CBY2
CCDC125
CCDC24
CCDC33
CDC16
CDT1
CEP44
CERCAM
COIL
CRACR2A
CRTC2
CTBP1
CYB5R2
DCLK1
DEPDC1B
DISC1
DLX6-AS1
EIF5A2
FAM9B
FBXO5
FOXN1
GORASP2
GTPBP8
HEMK1
IHO1
INCA1
INO80E
INPP5J
KCTD6
KDM1A
KRT36
LHX3
LZTS1
LZTS2
MAGED1
MAPK3
NAB2
NRBF2
NUP54
OPTN
PFKFB4
PIH1D2
PNMA5
POU6F2
PROSER3
PRPF31
PRR22
RAC1
RAD54B
RBM15B
RBP3
RBPMS
RSL24D1
RUNX1T1
SIAH1
SLC52A2
SMARCB1
SMUG1
SORBS3
SOX5
SPAG8
SSX2IP
STX2
SUV39H1
TEPSIN
TNIP1
TRIM27
TSC22D4
UBE2S
USP54
ZMAT1
63 interacting genes:
ABLIM1
AIFM1
APIP
ARHGAP9
BLZF1
CBX8
CCDC146
CCDC33
CCDC42
CCNK
CDC23
CDK5R1
CKS2
CLU
CTNNAL1
ENKD1
FBXW7
FRMD6
FXR2
GOLGA2
GORASP2
KPNA2
KRT40
LBP
LMO1
LMO2
LNX1
LRP2BP
MAD2L1
MTHFS
MYLIP
MYO15B
NIF3L1
NOC4L
NRBP1
NRBP2
PCBP1
PCDH17
PIH1D1
PIN1
POLR1C
PPL
PRKAA1
PRKAA2
PRNP
PSMA1
RACK1
SACS
SAT1
SMAD3
SMARCB1
SYT17
TEX11
TLE5
TRIM55
TRIM63
TSC22D1
TSPOAP1
UBLCP1
VBP1
ZBTB24
ZMYND10
ZNF580
Entrez ID
8697
81628
HPRD ID
07221
18231
Ensembl ID
ENSG00000094880
ENSG00000166925
Uniprot IDs
Q9UJX2
B4DKI8
Q9Y3Q8
PDB IDs
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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