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CDC23 and NAB2
Data Source:
BioGRID
(two hybrid)
CDC23
NAB2
Description
cell division cycle 23
NGFI-A binding protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Cytosol
Nucleus
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Identical Protein Binding
Biological Process
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Mitotic Metaphase Plate Congression
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Regulation Of Exit From Mitosis
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Endochondral Ossification
Regulation Of Transcription, DNA-templated
Schwann Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase III
Myelination
Regulation Of Epidermis Development
Positive Regulation Of Tau-protein Kinase Activity
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
NGF-stimulated transcription
NGF-stimulated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Resting heart rate (
27798624
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Asthma (
31361310
31959851
31619474
29273806
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Bipolar disorder (
31043756
)
IgE levels (
22075330
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
81 interacting genes:
ANAPC10
ANAPC13
ANKRD11
APOL1
ATRIP
BCAS3
BEGAIN
BHLHB9
BYSL
C21orf91
CBY2
CCDC125
CCDC24
CCDC33
CDC16
CDT1
CEP44
CERCAM
COIL
CRACR2A
CRTC2
CTBP1
CYB5R2
DCLK1
DEPDC1B
DISC1
DLX6-AS1
EIF5A2
FAM9B
FBXO5
FOXN1
GORASP2
GTPBP8
HEMK1
IHO1
INCA1
INO80E
INPP5J
KCTD6
KDM1A
KRT36
LHX3
LZTS1
LZTS2
MAGED1
MAPK3
NAB2
NRBF2
NUP54
OPTN
PFKFB4
PIH1D2
PNMA5
POU6F2
PROSER3
PRPF31
PRR22
RAC1
RAD54B
RBM15B
RBP3
RBPMS
RSL24D1
RUNX1T1
SIAH1
SLC52A2
SMARCB1
SMUG1
SORBS3
SOX5
SPAG8
SSX2IP
STX2
SUV39H1
TEPSIN
TNIP1
TRIM27
TSC22D4
UBE2S
USP54
ZMAT1
80 interacting genes:
ANK3
ANKRD11
CBX8
CCDC187
CCDC33
CCDC57
CCHCR1
CDC23
CTAG1A
CTAG1B
CTNNA3
CWF19L2
DDX6
DGCR6
DGCR6L
DRG2
EGR1
EGR2
ELOA
ENKD1
EXOC8
FAM9A
GCC1
GOLGA6L9
HSF2BP
JAKMIP2
KIF9
KIFC3
KRT34
KRT40
KRTAP10-3
KRTAP10-8
LENG1
LMNA
LNX1
MAPK3
MCM7
MCRS1
MDFI
MORF4L1
MORF4L2
NDOR1
NEDD9
NME7
NOTCH2NLA
NTAQ1
PHF1
PHOSPHO2
PIK3R3
PIN1
PLOD3
PRKAA2
PRKAB2
PSMA1
QARS1
RBPMS
RFC5
RINT1
SCNM1
SMARCD1
SORBS3
SPG21
SUMO1P1
TCEA2
TCEANC
TCHP
TGIF2LY
TLE5
TRAF2
TRIM23
TSGA10
TSGA10IP
TTC19
USP2
UTP14C
ZBED8
ZMAT2
ZMYND12
ZMYND19
ZNF417
Entrez ID
8697
4665
HPRD ID
07221
03854
Ensembl ID
ENSG00000094880
ENSG00000166886
Uniprot IDs
Q9UJX2
Q15742
PDB IDs
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
Enriched GO Terms of Interacting Partners
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