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CDC23 and ATRIP
Data Source:
BioGRID
(two hybrid)
CDC23
ATRIP
Description
cell division cycle 23
ATR interacting protein
Image
GO Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Cytosol
Nucleoplasm
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Protein Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Mitotic Metaphase Plate Congression
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Regulation Of Exit From Mitosis
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
DNA Damage Checkpoint
DNA Replication
DNA Repair
Interstrand Cross-link Repair
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Resting heart rate (
27798624
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Interacting Genes
81 interacting genes:
ANAPC10
ANAPC13
ANKRD11
APOL1
ATRIP
BCAS3
BEGAIN
BHLHB9
BYSL
C21orf91
CBY2
CCDC125
CCDC24
CCDC33
CDC16
CDT1
CEP44
CERCAM
COIL
CRACR2A
CRTC2
CTBP1
CYB5R2
DCLK1
DEPDC1B
DISC1
DLX6-AS1
EIF5A2
FAM9B
FBXO5
FOXN1
GORASP2
GTPBP8
HEMK1
IHO1
INCA1
INO80E
INPP5J
KCTD6
KDM1A
KRT36
LHX3
LZTS1
LZTS2
MAGED1
MAPK3
NAB2
NRBF2
NUP54
OPTN
PFKFB4
PIH1D2
PNMA5
POU6F2
PROSER3
PRPF31
PRR22
RAC1
RAD54B
RBM15B
RBP3
RBPMS
RSL24D1
RUNX1T1
SIAH1
SLC52A2
SMARCB1
SMUG1
SORBS3
SOX5
SPAG8
SSX2IP
STX2
SUV39H1
TEPSIN
TNIP1
TRIM27
TSC22D4
UBE2S
USP54
ZMAT1
22 interacting genes:
BRCA1
C1orf94
CCDC28B
CDC23
CDC6
CDK16
CEP164
CINP
FAAP100
FAM156A
LNX1
METTL21A
MID2
MOS
MX2
POLR1C
PRKDC
RPA3
SCG2
SPRY2
TASOR2
ZBTB14
Entrez ID
8697
84126
HPRD ID
07221
Ensembl ID
ENSG00000094880
ENSG00000164053
Uniprot IDs
Q9UJX2
A0A024R2U4
A0A024R307
Q8WXE1
PDB IDs
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
4IGK
4NB3
5YZ0
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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