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FRS3 and TSC1
Data Source:
BioGRID
(two hybrid)
FRS3
TSC1
Description
fibroblast growth factor receptor substrate 3
TSC complex subunit 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Growth Cone
Protein-containing Complex
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Chaperone Complex
Molecular Function
Fibroblast Growth Factor Receptor Binding
Protein Binding
Identical Protein Binding
Protein Binding
Hsp70 Protein Binding
GTPase Activating Protein Binding
ATPase Inhibitor Activity
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Hsp90 Protein Binding
Biological Process
MAPK Cascade
Signal Transduction
Fibroblast Growth Factor Receptor Signaling Pathway
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
RRNA Export From Nucleus
Regulation Of Translation
Potassium Ion Transport
Cell-matrix Adhesion
Negative Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Negative Regulation Of Translation
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATPase Activity
Response To Insulin
Negative Regulation Of GTPase Activity
Myelination
Memory T Cell Differentiation
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Cell Size
Regulation Of Protein Kinase Activity
Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Cellular Response To Oxygen-glucose Deprivation
Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
RAF/MAP kinase cascade
Activated NTRK2 signals through FRS2 and FRS3
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Drugs
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Menarche (age at onset) (
25231870
)
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Interacting Genes
111 interacting genes:
ADAMTSL4
ANAPC11
ANKRD55
ATP23
BLZF1
BMPR2
C11orf1
C11orf45
C19orf54
C22orf39
CATSPER1
CBY2
CCDC33
CCN3
CDPF1
COL8A1
COPS3
CREB5
CYSRT1
DCDC2B
DDX5
DMRT3
DPEP2NB
ECM1
ESM1
FGFR1
GATA1
GPRIN2
GRB14
GRB2
HOXA1
HOXD12
ID2
ID3
IKZF3
INCA1
ISY1-RAB43
KARS1
KATNBL1
KIAA0408
KPRP
KRT31
KRT33B
KRT34
KRT35
KRT76
KRTAP1-1
KRTAP10-8
KRTAP11-1
KRTAP3-1
KRTAP3-2
KRTAP6-2
LINGO1
LRRC18
MAPK1
MATK
MBD3L1
MIIP
NADSYN1
NBPF19
NOTCH2NLA
NTRK1
NTRK2
NUMB
PCSK5
PDLIM7
PIH1D2
PLB1
PLLP
PLSCR1
POF1B
PPP1R32
PRDM6
PRKCI
PTPN11
RFX6
RIMBP3C
RND1
SCNM1
SH2B1
SLAIN1
SLC22A18AS
SOCS6
SPATA12
SPRY2
STH
STK16
TCF4
TCP10L
TGM7
TLE5
TNS1
TRAF4
TRIP6
TSC1
TSGA10IP
TSPAN4
UNKL
VASP
VGLL3
WDR83
WWOX
YPEL3
ZMIZ2
ZNF124
ZNF417
ZNF438
ZNF446
ZNF552
ZNF69
ZSCAN30
99 interacting genes:
AKT1
APPL2
AQP1
ARAF
ARID5A
ATXN1
AURKA
BAG3
BECN1
C1orf94
CCDC120
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CHCHD2
CSTF2
DMRT3
DOK5
ENKD1
EZR
FAM110A
FAM222B
FGFR4
FOXH1
FRS3
GLIS2
GPANK1
HOXC8
HR
HSH2D
IGFN1
IKBKB
KAT2A
KDM1A
LATS2
LENG1
LMO2
MAP2K5
MAPK14
MSN
MYC
MYLIP
MYOZ3
NEFL
NF2
PATL1
PATZ1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPP1R18
PPP1R32
PRMT6
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
SAMD11
SAMD7
SH2D2A
SHC3
SMG9
SOX4
SPAG8
SUOX
TBC1D7
TBX6
TCF7L2
TFAP2D
TLE5
TNS2
TSC2
TSGA10IP
TSHZ3
VENTX
VEZF1
VGLL3
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF587
ZNF765
Entrez ID
10817
7248
HPRD ID
06373
05594
Ensembl ID
ENSG00000137218
ENSG00000165699
Uniprot IDs
A0A140VJJ7
O43559
A0A2R8Y5S3
Q32NF0
Q86WV8
Q92574
X5D9D2
PDB IDs
2KUP
2KUQ
2YS5
2YT2
4Z6Y
5EJC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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