FRS3 and NADSYN1

Data Source:
BioGRID (two hybrid)

		FRS3	NADSYN1
Description		fibroblast growth factor receptor substrate 3	NAD synthetase 1
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GO Annotations	Cellular Component	Plasma Membrane	Cytoplasm Cytosol
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	NAD+ Synthase (glutamine-hydrolyzing) Activity Glutaminase Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	NAD Biosynthetic Process NAD Metabolic Process 'de Novo' NAD Biosynthetic Process
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3	Nicotinate metabolism
Drugs			Glutamic acid
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Systemic lupus erythematosus ( 26502338) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 29343764 20418485) Vitamin D levels (dietary vitamin D intake interaction) ( 29343764)
Interacting Genes		111 interacting genes: ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C11orf1 C11orf45 C19orf54 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PPP1R32 PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SCNM1 SH2B1 SLAIN1 SLC22A18AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30	13 interacting genes: ANKS1A COL8A1 CREB5 CUTC FRS3 GPANK1 HGS HOXC8 MYO15B NOXA1 NTAQ1 TFG UPF1
Entrez ID		10817	55191
HPRD ID		06373	16309
Ensembl ID		ENSG00000137218	ENSG00000172890
Uniprot IDs		A0A140VJJ7 O43559	Q6IA69
PDB IDs		2KUP 2KUQ 2YS5 2YT2	6OFB
Enriched GO Terms of Interacting Partners?
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