PAIP1 and EIF4A1

Data Source:
HPRD (in vitro, in vivo)

		PAIP1	EIF4A1
Description		poly(A) binding protein interacting protein 1	eukaryotic translation initiation factor 4A1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Translation Activator Activity	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation MRNA Stabilization	Cytoplasmic Translational Initiation Translational Initiation Viral Process
Pathways		Deadenylation of mRNA	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			Copper
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		8 interacting genes: EIF3A EIF3B EIF4A1 MYB PABPC1 RND1 UBR5 WWP2	13 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 PAIP1 PLPPR4 PRMT1 SUMO2 TNKS UCHL5 UPF2
Entrez ID		10605	1973
HPRD ID		05539	04030
Ensembl ID		ENSG00000172239	ENSG00000161960
Uniprot IDs		Q9H074	P60842
PDB IDs		1JH4 3NTW 3RK6	2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW
Enriched GO Terms of Interacting Partners?
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