PAIP1 and UBR5

Data Source:
HPRD (in vitro)

		PAIP1	UBR5
Description		poly(A) binding protein interacting protein 1	ubiquitin protein ligase E3 component n-recognin 5
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Protein Binding Translation Activator Activity	RNA Binding Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity
	Biological Process	Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation MRNA Stabilization	Protein Polyubiquitination DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Gene Expression Viral Process Positive Regulation Of Protein Import Into Nucleus Progesterone Receptor Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair
Pathways		Deadenylation of mRNA
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Chromosomal aberration frequency (total) ( 31586183) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		8 interacting genes: EIF3A EIF3B EIF4A1 MYB PABPC1 RND1 UBR5 WWP2	30 interacting genes: BARD1 CIB1 CSPP1 DYRK2 ERG GSK3B KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 NR1I2 OTUD5 PAIP1 PAIP2 PCK1 PGR SATB1 SMAD2 SOX2 TCEA1 TOPBP1 TXNIP UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3 ZNF207
Entrez ID		10605	51366
HPRD ID		05539	06436
Ensembl ID		ENSG00000172239	ENSG00000104517
Uniprot IDs		Q9H074	O95071
PDB IDs		1JH4 3NTW 3RK6	1I2T 2QHO 3PT3
Enriched GO Terms of Interacting Partners?
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