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LAMTOR5 and ECT2
Data Source:
BioGRID
(two hybrid)
LAMTOR5
ECT2
Description
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
epithelial cell transforming 2
Image
GO Annotations
Cellular Component
Lysosome
Lysosomal Membrane
Cytosol
Protein-containing Complex
Ragulator Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cell-cell Junction
Bicellular Tight Junction
Cell Cortex
Nuclear Body
Midbody
Cleavage Furrow
Mitotic Spindle
Centralspindlin Complex
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Molecular Adaptor Activity
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Small GTPase Binding
Protein Homodimerization Activity
Biological Process
Cell Cycle Arrest
Regulation Of Cell Size
Response To Virus
Positive Regulation Of Gene Expression
Regulation Of Macroautophagy
Viral Genome Replication
Positive Regulation Of TOR Signaling
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Localization To Lysosome
Cellular Response To Amino Acid Stimulus
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of TORC1 Signaling
Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Mitotic Cytokinesis
Cell Morphogenesis
G Protein-coupled Receptor Signaling Pathway
Nervous System Development
Protein Transport
Cell Differentiation
Activation Of Protein Kinase Activity
Positive Regulation Of Cytokinesis
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of GTPase Activity
Positive Regulation Of Neuron Differentiation
Regulation Of Protein Kinase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Protein Homooligomerization
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Cellular Response To Hydrogen Peroxide
Bicellular Tight Junction Assembly
Cellular Response To Calcium Ion
Cellular Response To Ionizing Radiation
Activation Of GTPase Activity
Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Red cell distribution width (
32888494
)
Interacting Genes
64 interacting genes:
ACAA2
AKR1C2
ALB
ANKRD46
ASGR1
BHMT
C9
CD74
CEP126
CEP70
CFB
CLIC5
DBI
DNAJA3
ECT2
EEF1A1
EIF3A
EIF4B
GAPDH
GIT1
GIT2
GPRASP1
HEBP2
HSPA9
ITGB1
KEAP1
KIF1B
KMT2E
LAMTOR4
LRIF1
MAF1
MCPH1
MED12L
MEOX2
MKLN1
MT2A
MYF6
MYH3
MYOG
NCOA6
PDK1
PEG10
PPARA
RABIF
RBP4
SERPINA1
SFPQ
SHB
SKP1
SMAD4
SNX5
TAF9
TBC1D4
TCAP
TCF12
TGFB1
TOP2B
TP53
TRIM55
TRIM63
UTP14A
YTHDC1
ZBTB16
ZNF592
38 interacting genes:
ABR
C2orf42
CCDC91
CD19
CDK1
CHST10
CSTB
EIF4A2
EIF5B
ELOC
ERAL1
F2RL2
FANCM
GGN
ILVBL
KLHL20
LAMTOR5
MBD1
MT-CO2
MT2A
NOMO1
NPC2
OOSP2
OTUB1
PARD6A
PCOLCE
PLK1
POMP
PSMA6
RACGAP1
RHOG
RPS20
SNRNP200
SPATA22
SRPK2
THAP11
UBB
VDAC2
Entrez ID
10542
1894
HPRD ID
09773
11860
Ensembl ID
ENSG00000134248
ENSG00000114346
Uniprot IDs
A0A0C4DGV4
O43504
Q9H8V3
PDB IDs
3MS6
3MSH
5VOK
5X6U
5X6V
5Y38
5Y39
5Y3A
5YK3
6B9X
6EHP
6EHR
6NZD
6U62
6ULG
6WJ2
6WJ3
3L46
4N40
6L30
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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