ECT2 and CSTB

Data Source:
BioGRID (two hybrid)

		ECT2	CSTB
Description		epithelial cell transforming 2	cystatin B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	Mitotic Cytokinesis Cell Morphogenesis G Protein-coupled Receptor Signaling Pathway Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly	Adult Locomotory Behavior Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Negative Regulation Of Proteolysis
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Neutrophil degranulation
Drugs			Cupric Chloride
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		38 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB VDAC2	8 interacting genes: CST3 CTSB CTSD CTSH CTSL ECT2 RAD21 SPRY2
Entrez ID		1894	1476
HPRD ID		11860	03091
Ensembl ID		ENSG00000114346	ENSG00000160213
Uniprot IDs		Q9H8V3	P04080 Q76LA1
PDB IDs		3L46 4N40 6L30	1STF 2OCT 4N6V
Enriched GO Terms of Interacting Partners?
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