LAMTOR5 and AKR1C2

Data Source:
BioGRID (two hybrid)

		LAMTOR5	AKR1C2
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	aldo-keto reductase family 1 member C2
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Protein-containing Complex Ragulator Complex	Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	Alditol:NADP+ 1-oxidoreductase Activity Estradiol 17-beta-dehydrogenase Activity Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Carboxylic Acid Binding Bile Acid Binding Androsterone Dehydrogenase Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity
	Biological Process	Cell Cycle Arrest Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Prostaglandin Metabolic Process G Protein-coupled Receptor Signaling Pathway Digestion Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Epithelial Cell Differentiation Progesterone Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Positive Regulation Of Protein Kinase B Signaling Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs			NADH Ursodeoxycholic acid Nicotinamide adenine dinucleotide phosphate Chenodeoxycholic acid Epitestosterone
Diseases
GWAS			Height ( 28552196) Longevity ( 26912274)
Interacting Genes		64 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LAMTOR4 LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592	1 interacting genes: LAMTOR5
Entrez ID		10542	1646
HPRD ID		09773	11857
Ensembl ID		ENSG00000134248	ENSG00000151632
Uniprot IDs		A0A0C4DGV4 O43504	B4DK69 P52895
PDB IDs		3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3	1IHI 1J96 1XJB 2HDJ 2IPJ 4JQ1 4JQ2 4JQ3 4JQ4 4JQA 4JTQ 4JTR 4L1W 4L1X 4XO6 4XO7
Enriched GO Terms of Interacting Partners?
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