LAMTOR5 and MKLN1

Data Source:
BioGRID (two hybrid)

		LAMTOR5	MKLN1
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	muskelin 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Protein-containing Complex Ragulator Complex	Ubiquitin Ligase Complex Ruffle Nucleoplasm Cytoplasm Cytosol Cell Cortex Postsynapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cell Cycle Arrest Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Regulation Of Receptor Internalization Cell-matrix Adhesion Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Reorganization
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS			Asthma (childhood onset) ( 23829686) Bipolar disorder ( 31043756) Bipolar disorder (early onset) ( 27769005) Cutaneous malignant melanoma ( 32341527) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Hyperglycemia in higher physical activity ( 30327367) Hypertension ( 28273873) Lung cancer in never smokers ( 28604730) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Myeloproliferative neoplasms ( 33057200) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Pancreatic cancer ( 25086665) PR interval ( 30046033 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Systolic blood pressure ( 28135244) Vitamin D levels ( 25208829) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		64 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LAMTOR4 LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592	5 interacting genes: CYREN LAMTOR5 MAEA PTGER3 ZBTB2
Entrez ID		10542	4289
HPRD ID		09773	16129
Ensembl ID		ENSG00000134248	ENSG00000128585
Uniprot IDs		A0A0C4DGV4 O43504	B4DG30 Q9UL63
PDB IDs		3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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