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LAMTOR5 and TOP2B
Data Source:
BioGRID
(two hybrid)
LAMTOR5
TOP2B
Description
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
DNA topoisomerase II beta
Image
GO Annotations
Cellular Component
Lysosome
Lysosomal Membrane
Cytosol
Protein-containing Complex
Ragulator Complex
Heterochromatin
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Ribonucleoprotein Complex
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Molecular Adaptor Activity
DNA Binding
Chromatin Binding
DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity
Protein Kinase C Binding
ATP Binding
Protein C-terminus Binding
Enzyme Binding
Histone Deacetylase Binding
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Cell Cycle Arrest
Regulation Of Cell Size
Response To Virus
Positive Regulation Of Gene Expression
Regulation Of Macroautophagy
Viral Genome Replication
Positive Regulation Of TOR Signaling
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Localization To Lysosome
Cellular Response To Amino Acid Stimulus
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of TORC1 Signaling
Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Resolution Of Meiotic Recombination Intermediates
Sister Chromatid Segregation
Neuron Migration
DNA Topological Change
Axonogenesis
Forebrain Development
Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Pathways
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
SUMOylation of DNA replication proteins
Drugs
Dexrazoxane
Daunorubicin
Etoposide
Dactinomycin
Phosphoaminophosphonic Acid-Adenylate Ester
Amonafide
Technetium Tc-99m ciprofloxacin
ZEN-012
Becatecarin
Declopramide
3'-THIO-THYMIDINE-5'-PHOSPHATE
Diseases
GWAS
Chronic obstructive pulmonary disease (
30804561
)
Interacting Genes
64 interacting genes:
ACAA2
AKR1C2
ALB
ANKRD46
ASGR1
BHMT
C9
CD74
CEP126
CEP70
CFB
CLIC5
DBI
DNAJA3
ECT2
EEF1A1
EIF3A
EIF4B
GAPDH
GIT1
GIT2
GPRASP1
HEBP2
HSPA9
ITGB1
KEAP1
KIF1B
KMT2E
LAMTOR4
LRIF1
MAF1
MCPH1
MED12L
MEOX2
MKLN1
MT2A
MYF6
MYH3
MYOG
NCOA6
PDK1
PEG10
PPARA
RABIF
RBP4
SERPINA1
SFPQ
SHB
SKP1
SMAD4
SNX5
TAF9
TBC1D4
TCAP
TCF12
TGFB1
TOP2B
TP53
TRIM55
TRIM63
UTP14A
YTHDC1
ZBTB16
ZNF592
17 interacting genes:
CD3E
CSNK2B
ERG
HDAC1
HDAC2
LAMTOR5
MAPK3
RANBP2
RARA
SUMO1
SUMO2
TOP2A
TOPBP1
TP53
UBE2I
XPO1
XRCC5
Entrez ID
10542
7155
HPRD ID
09773
00537
Ensembl ID
ENSG00000134248
ENSG00000077097
Uniprot IDs
A0A0C4DGV4
O43504
Q02880
Q59H80
PDB IDs
3MS6
3MSH
5VOK
5X6U
5X6V
5Y38
5Y39
5Y3A
5YK3
6B9X
6EHP
6EHR
6NZD
6U62
6ULG
6WJ2
6WJ3
3QX3
4G0U
4G0V
4G0W
4J3N
5GWI
5GWJ
5ZAD
5ZEN
5ZQF
5ZRF
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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