LAMTOR5 and BHMT

Data Source:
BioGRID (two hybrid)

		LAMTOR5	BHMT
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	betaine--homocysteine S-methyltransferase
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Protein-containing Complex Ragulator Complex	Cytosol Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	Zinc Ion Binding Betaine-homocysteine S-methyltransferase Activity
	Biological Process	Cell Cycle Arrest Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Sulfur Amino Acid Metabolic Process Protein Methylation Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Choline Catabolic Process S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Sulfur amino acid metabolism Choline catabolism
Drugs			Methionine S-(D-Carboxybutyl)-L-Homocysteine
Diseases
GWAS			Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23823483 23378610) Toenail selenium levels ( 25343990)
Interacting Genes		64 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LAMTOR4 LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592	6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5
Entrez ID		10542	635
HPRD ID		09773	04200
Ensembl ID		ENSG00000134248	ENSG00000145692
Uniprot IDs		A0A0C4DGV4 O43504	Q93088 V9HWA4
PDB IDs		3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3	1LT7 1LT8 4M3P
Enriched GO Terms of Interacting Partners?
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