CNKSR1 and RALGDS

Data Source:
HPRD (in vivo)

		CNKSR1	RALGDS
Description		connector enhancer of kinase suppressor of Ras 1	ral guanine nucleotide dissociation stimulator
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex	Nucleus Cytosol Brush Border
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction	Ras Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		10256	5900
HPRD ID		11937	03371
Ensembl ID		ENSG00000142675	ENSG00000160271
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	Q12967 Q8N4Y1
PDB IDs		1WWV	1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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