CNKSR1 and CYTH4

Data Source:
BioGRID (two hybrid)

		CNKSR1	CYTH4
Description		connector enhancer of kinase suppressor of Ras 1	cytohesin 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex	Golgi Membrane Cytosol Plasma Membrane Centriolar Satellite Intercellular Bridge
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction	Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Intra-Golgi traffic
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Uterine fibroids ( 28836065)
Interacting Genes		23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	24 interacting genes: AMOTL2 CBY2 CCDC120 CCDC197 CCDC6 CNKSR1 CTAG1A CTAG1B FOS FOSB HOOK2 IPCEF1 KANK2 KIFC3 KRT15 KRT16 KRT34 KRT40 PCM1 PSMB1 SNAPC5 SYCE1L TRIM54 USHBP1
Entrez ID		10256	27128
HPRD ID		11937	07354
Ensembl ID		ENSG00000142675	ENSG00000100055
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	B4E2V8 Q9UIA0
PDB IDs		1WWV
Enriched GO Terms of Interacting Partners?
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