CNKSR1 and CADM4

Data Source:
HPRD (two hybrid, in vivo)

		CNKSR1	CADM4
Description		connector enhancer of kinase suppressor of Ras 1	cell adhesion molecule 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex	Integral Component Of Membrane Cell Leading Edge Cell-cell Contact Zone
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Vascular Endothelial Growth Factor Receptor 1 Binding Vascular Endothelial Growth Factor Receptor 2 Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction	Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Cell Adhesion Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Rac Protein Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Wound Healing Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Cell Motility
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	3 interacting genes: CNKSR1 CSNK1E DYNC1I1
Entrez ID		10256	199731
HPRD ID		11937	17141
Ensembl ID		ENSG00000142675	ENSG00000105767
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	Q8NFZ8
PDB IDs		1WWV
Enriched GO Terms of Interacting Partners?
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