CNKSR1 and CYTH2

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CNKSR1	CYTH2
Description		connector enhancer of kinase suppressor of Ras 1	cytohesin 2
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Growth Cone
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction	Endocytosis Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Intra-Golgi traffic
Drugs			Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Abstraction and mental flexibility ( 31596458)
Interacting Genes		23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	31 interacting genes: ADORA2A ALDOA APC ARF1 ARF6 ARFGAP1 ARL4A ARL4D ARRB1 ARRB2 ATP6V0A1 ATP6V0A2 ATP6V0A4 CCDC120 CNKSR1 CUX1 CYTIP DOCK1 GGA3 GNAQ INAVA IPCEF1 ITGB2 MAPK6 PIK3CA PNPLA2 PRKCA PRKCB PRKCG TCIRG1 TRIM23
Entrez ID		10256	9266
HPRD ID		11937	03925
Ensembl ID		ENSG00000142675	ENSG00000105443
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	Q99418
PDB IDs		1WWV	1PBV 1R8M 1R8Q 1R8S 1S9D 4JMI 4JMO 4JWL 4JXH 4L5M 4Z21
Enriched GO Terms of Interacting Partners?
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