ADAM33 and SPINT1

Data Source:
BioGRID (two hybrid)

		ADAM33	SPINT1
Description		ADAM metallopeptidase domain 33	serine peptidase inhibitor, Kunitz type 1
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GO Annotations	Cellular Component	Integral Component Of Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Zinc Ion Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation
Pathways			MET Receptor Activation Signaling by MST1
Drugs
Diseases		Asthma
GWAS		Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)	Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21	23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5
Entrez ID		80332	6692
HPRD ID		06173	05494
Ensembl ID		ENSG00000149451	ENSG00000166145
Uniprot IDs		A2A2L3 Q9BZ11	O43278
PDB IDs		1R54 1R55	1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
Enriched GO Terms of Interacting Partners?
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