SPINT1 and ADAM33

Data Source:
BioGRID (two hybrid)

		SPINT1	ADAM33
Description		serine peptidase inhibitor, Kunitz type 1	ADAM metallopeptidase domain 33
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Proteolysis
Pathways		MET Receptor Activation Signaling by MST1
Drugs
Diseases			Asthma
GWAS		Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5	33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21
Entrez ID		6692	80332
HPRD ID		05494	06173
Ensembl ID		ENSG00000166145	ENSG00000149451
Uniprot IDs		O43278	A2A2L3 Q9BZ11
PDB IDs		1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V	1R54 1R55
Enriched GO Terms of Interacting Partners?
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