SPINT1 and TSPAN33

Data Source:
BioGRID (two hybrid)

		SPINT1	TSPAN33
Description		serine peptidase inhibitor, Kunitz type 1	tetraspanin 33
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Cell Surface Pore Complex Tetraspanin-enriched Microdomain
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Protein Binding Enzyme Binding
	Biological Process	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Cellular Protein Metabolic Process Pore Complex Assembly Protein Maturation Protein Localization To Plasma Membrane
Pathways		MET Receptor Activation Signaling by MST1	Amyloid fiber formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Estimated glomerular filtration rate ( 31015462) Ulcerative colitis ( 23128233)
Interacting Genes		23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5	27 interacting genes: CHRM2 CISD2 CLDN7 COQ9 DARS2 ERGIC3 FAM209A GAD2 GJA8 GORAB GPR152 GPX8 KCNK5 LHFPL5 LMNA MFF MGST3 MTIF3 NEMP1 PLEKHO1 RELL2 SHISA4 SIT1 SLC35C2 SPINT1 TMEM106C TMEM45B
Entrez ID		6692	340348
HPRD ID		05494	14669
Ensembl ID		ENSG00000166145	ENSG00000158457
Uniprot IDs		O43278	Q86UF1
PDB IDs		1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
Enriched GO Terms of Interacting Partners?
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