SPINT1 and SLC38A7

Data Source:
BioGRID (two hybrid)

		SPINT1	SLC38A7
Description		serine peptidase inhibitor, Kunitz type 1	solute carrier family 38 member 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Integral Component Of Membrane Axon Neuronal Cell Body
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	L-histidine Transmembrane Transporter Activity L-glutamate Transmembrane Transporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-asparagine Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity L-methionine Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity
	Biological Process	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Amino Acid Transmembrane Transport Sodium Ion Transport Asparagine Transport Glutamine Transport Branched-chain Amino Acid Transport L-alanine Transport L-glutamate Transmembrane Transport Methionine Transport L-serine Transport L-aspartate Transmembrane Transport L-histidine Transmembrane Transport
Pathways		MET Receptor Activation Signaling by MST1
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer ( 30648747) QT interval ( 19305408) Schizophrenia ( 25056061 29483656)
Interacting Genes		23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5	52 interacting genes: ACBD5 AMIGO1 APH1A AQP2 AQP9 ARL13B BTNL9 CLCN7 CLDN7 CLEC10A CPLX4 CREB3L3 CYB561 CYB5R3 EDA ERGIC3 ERP29 EVI2B FAM209A FCER1G FKBP7 GJA8 GJB5 GPR152 GPR42 IL10RA KIR2DL3 LMNA LY6G6C LYVE1 MMGT1 MUC1 ODF4 OPRM1 PANX1 PDCD1LG2 RNF5 SCN3B SERP2 SHISAL1 SLC10A1 SLC16A2 SLC18A1 SLC23A2 SLC30A2 SPINT1 SSMEM1 SYPL2 TMEM237 TMEM52B TSPAN8 YIPF6
Entrez ID		6692	55238
HPRD ID		05494	07701
Ensembl ID		ENSG00000166145	ENSG00000103042
Uniprot IDs		O43278	H3BMC5 Q9NVC3
PDB IDs		1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
Enriched GO Terms of Interacting Partners?
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