ADAM33 and SEC11A

Data Source:
BioGRID (two hybrid)

		ADAM33	SEC11A
Description		ADAM metallopeptidase domain 33	SEC11 homolog A, signal peptidase complex subunit
Image			No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Metalloendopeptidase Activity Zinc Ion Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity
	Biological Process	Proteolysis	Signal Peptide Processing
Pathways			SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases		Asthma
GWAS		Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)
Interacting Genes		33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21	5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6
Entrez ID		80332	23478
HPRD ID		06173	07503
Ensembl ID		ENSG00000149451	ENSG00000140612
Uniprot IDs		A2A2L3 Q9BZ11	A0A024RC78 H0YKT4 P67812
PDB IDs		1R54 1R55
Enriched GO Terms of Interacting Partners?
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