CDK5RAP2 and TBC1D4

Data Source:
HPRD (two hybrid)

		CDK5RAP2	TBC1D4
Description		CDK5 regulatory subunit associated protein 2	TBC1 domain family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Spindle Pole Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Gamma-tubulin Ring Complex Cell Junction Microtubule Plus-end Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle Pole	Cytosol Vesicle
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Gamma-tubulin Binding	GTPase Activator Activity Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Chromosome Segregation Centrosome Cycle Centriole Replication Brain Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Neurogenesis Microtubule Organizing Center Organization Positive Regulation Of Microtubule Polymerization Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Ciliary Basal Body-plasma Membrane Docking	Intracellular Protein Transport Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus Activation Of GTPase Activity
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Asthma ( 27611488) Height ( 28552196) Photic sneeze reflex ( 27182965) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 24782177)	Diabetic retinopathy ( 23562823) Eosinophil counts ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		25 interacting genes: ABCA2 CDK5 CDK5R1 CLIP4 CRMP1 EEF1G ERG28 FBXO25 HAP1 KAT5 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1	16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1
Entrez ID		55755	9882
HPRD ID		09740	18164
Ensembl ID		ENSG00000136861	ENSG00000136111
Uniprot IDs		A0A0A0MRG9 B3KVI2 B9EG74 Q7Z3M0 Q96SN8	A0A3B3IRT3 O60343
PDB IDs			3QYB
Enriched GO Terms of Interacting Partners?
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