TBC1D4 and EP400

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TBC1D4	EP400
Description		TBC1 domain family member 4	E1A binding protein p400
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Vesicle	Swr1 Complex Nucleoplasm Nuclear Speck NuA4 Histone Acetyltransferase Complex
	Molecular Function	GTPase Activator Activity Protein Binding	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Protein Antigen Binding
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus Activation Of GTPase Activity	Histone H4 Acetylation Histone H2A Acetylation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane	Formation of Senescence-Associated Heterochromatin Foci (SAHF) DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Eosinophil counts ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Body mass index ( 26426971) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1	13 interacting genes: ALAS1 BRD8 KAT5 MNS1 MYC NTAQ1 POLR1C RAD51 SUMO2 TBC1D4 TRAF2 TRRAP ZGPAT
Entrez ID		9882	57634
HPRD ID		18164	09378
Ensembl ID		ENSG00000136111	ENSG00000183495
Uniprot IDs		A0A3B3IRT3 O60343	Q96L91
PDB IDs		3QYB
Enriched GO Terms of Interacting Partners?
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