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CDK5RAP2 and HAP1
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
CDK5RAP2
HAP1
Description
CDK5 regulatory subunit associated protein 2
huntingtin associated protein 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Pericentriolar Material
Spindle Pole
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Microtubule
Gamma-tubulin Ring Complex
Cell Junction
Microtubule Plus-end
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Mitotic Spindle Pole
Nucleolus
Mitochondrion
Lysosome
Early Endosome
Autophagosome
Endoplasmic Reticulum
Centrosome
Centriole
Cytosol
Cytoskeleton
Synaptic Vesicle
Actin Cytoskeleton
Inclusion Body
Dendrite
Growth Cone
Cytoplasmic Vesicle
Dendritic Spine
Axon Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
Protein Binding
Calmodulin Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Gamma-tubulin Binding
Signaling Receptor Binding
Protein Binding
Myosin Binding
Ion Channel Binding
Brain-derived Neurotrophic Factor Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Establishment Of Mitotic Spindle Orientation
Microtubule Cytoskeleton Organization
Microtubule Bundle Formation
Chromosome Segregation
Centrosome Cycle
Centriole Replication
Brain Development
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Neurogenesis
Microtubule Organizing Center Organization
Positive Regulation Of Microtubule Polymerization
Regulation Of Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Centriole Replication
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Ciliary Basal Body-plasma Membrane Docking
Protein Targeting
Exocytosis
Autophagy
Chemical Synaptic Transmission
Brain Development
Anterograde Axonal Transport
Retrograde Axonal Transport
Protein Localization
Regulation Of Exocytosis
Cerebellum Development
Hypothalamus Cell Differentiation
Neurogenesis
Cell Projection Organization
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Positive Regulation Of Synaptic Transmission, GABAergic
Positive Regulation Of Neurotrophin Production
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Vesicle Transport Along Microtubule
Neurotrophin TRK Receptor Signaling Pathway
Mitochondrion Distribution
Positive Regulation Of Neurogenesis
Anterograde Axonal Transport Of Mitochondrion
Negative Regulation Of Amyloid-beta Formation
Regulation Of Organelle Transport Along Microtubule
Positive Regulation Of Non-motile Cilium Assembly
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Drugs
Diseases
Primary microcephaly (MCPH)
GWAS
Asthma (
27611488
)
Height (
28552196
)
Photic sneeze reflex (
27182965
)
Response to statin therapy (
20339536
)
Rheumatoid arthritis (
24782177
)
Developmental language disorder (syntactic complexity) (
27016271
)
Esophageal cancer (squamous cell) (
22960999
)
Interacting Genes
25 interacting genes:
ABCA2
CDK5
CDK5R1
CLIP4
CRMP1
EEF1G
ERG28
FBXO25
HAP1
KAT5
LUC7L2
MAGEH1
MAPRE1
NEFL
PCBD1
PTN
RBM48
REPS2
SENP2
STARD9
STK36
TBC1D4
TRIM37
TSNAX
ZPR1
93 interacting genes:
AEN
ANTKMT
APLP1
ATP5MF
BARD1
BRD7
C1orf216
C2CD6
C7orf25
C8orf33
CBX8
CCDC113
CCDC13
CDC73
CDK18
CDK5RAP2
COL9A2
CRIP1
DCTN1
DDX49
DEFB1
EIF3E
FAM50B
FEZ1
GABARAPL2
GADD45G
GIT1
GPRASP2
HDAC4
HGS
HMOX2
HOXB5
HSPA1A
HSPA4
HTT
IMMT
ING5
KAT5
KAT7
KATNBL1
KBTBD7
KPNA2
LRIF1
LUC7L2
MPP3
MRPS9
MSGN1
NAP1L5
NDUFB9
NEUROD1
NIPSNAP3A
NOD2
NOP53
PABPC4
PCM1
PDCD7
PFDN1
PKN1
PPID
PPOX
PPP1R18
PRPF31
PSMD11
RER1
RHPN1
RIF1
RPS10
RPS25
SCNM1
SNAPIN
SRSF4
STX5
TAF1D
TBP
TIMM17A
TNNT1
TNNT3
TOMM20
TSPYL1
UTP3
VIM
ZFP1
ZMAT2
ZNF124
ZNF20
ZNF24
ZNF33B
ZNF490
ZNF572
ZNF575
ZNF648
ZNF691
ZNF835
Entrez ID
55755
9001
HPRD ID
09740
02972
Ensembl ID
ENSG00000136861
ENSG00000173805
Uniprot IDs
A0A0A0MRG9
B3KVI2
B9EG74
Q7Z3M0
Q96SN8
P54257
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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