CDK5RAP2 and ABCA2

Data Source:
HPRD (two hybrid)

		CDK5RAP2	ABCA2
Description		CDK5 regulatory subunit associated protein 2	ATP binding cassette subfamily A member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Spindle Pole Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Gamma-tubulin Ring Complex Cell Junction Microtubule Plus-end Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle Pole	Lysosome Lysosomal Membrane Endosome Microtubule Organizing Center Plasma Membrane Endosome Membrane Membrane Integral Component Of Membrane Cytoplasmic Vesicle ATP-binding Cassette (ABC) Transporter Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Gamma-tubulin Binding	Nucleotide Binding Lipid Transporter Activity ATP Binding ATPase Activity ATPase-coupled Transmembrane Transporter Activity Endopeptidase Regulator Activity Ceramide Floppase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Chromosome Segregation Centrosome Cycle Centriole Replication Brain Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Neurogenesis Microtubule Organizing Center Organization Positive Regulation Of Microtubule Polymerization Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Ciliary Basal Body-plasma Membrane Docking	Ganglioside Metabolic Process Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Sphingomyelin Metabolic Process Glycosphingolipid Metabolic Process Lipid Transport Locomotory Behavior Regulation Of Cholesterol Esterification Central Nervous System Myelin Formation Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Intracellular Cholesterol Transport Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Drug Cholesterol Homeostasis Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Sphingosine Biosynthetic Process Response To Steroid Hormone Regulation Of Endopeptidase Activity Transmembrane Transport Regulation Of Protein Glycosylation Response To Cholesterol Negative Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Cholesterol Efflux Ceramide Translocation Transport Across Blood-brain Barrier Negative Regulation Of Cholesterol Esterification Regulation Of Post-translational Protein Modification Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Low-density Lipoprotein Receptor Activity Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Protein Localization To Cell Surface
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	ABC transporters in lipid homeostasis
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Asthma ( 27611488) Height ( 28552196) Photic sneeze reflex ( 27182965) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 24782177)	Adverse response to drug ( 30420678) White blood cell count ( 32888494)
Interacting Genes		25 interacting genes: ABCA2 CDK5 CDK5R1 CLIP4 CRMP1 EEF1G ERG28 FBXO25 HAP1 KAT5 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1	4 interacting genes: CACNA1A CDK5RAP2 DRD2 HTR6
Entrez ID		55755	20
HPRD ID		09740	08967
Ensembl ID		ENSG00000136861	ENSG00000107331
Uniprot IDs		A0A0A0MRG9 B3KVI2 B9EG74 Q7Z3M0 Q96SN8	Q9BZC7
PDB IDs
Enriched GO Terms of Interacting Partners?
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