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CDK5RAP2 and ABCA2
Data Source:
HPRD
(two hybrid)
CDK5RAP2
ABCA2
Description
CDK5 regulatory subunit associated protein 2
ATP binding cassette subfamily A member 2
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Pericentriolar Material
Spindle Pole
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Microtubule
Gamma-tubulin Ring Complex
Cell Junction
Microtubule Plus-end
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Mitotic Spindle Pole
Lysosome
Lysosomal Membrane
Endosome
Microtubule Organizing Center
Plasma Membrane
Endosome Membrane
Membrane
Integral Component Of Membrane
Cytoplasmic Vesicle
ATP-binding Cassette (ABC) Transporter Complex
Intracellular Membrane-bounded Organelle
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
Protein Binding
Calmodulin Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Gamma-tubulin Binding
Nucleotide Binding
Lipid Transporter Activity
ATP Binding
ATPase Activity
ATPase-coupled Transmembrane Transporter Activity
Endopeptidase Regulator Activity
Ceramide Floppase Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Establishment Of Mitotic Spindle Orientation
Microtubule Cytoskeleton Organization
Microtubule Bundle Formation
Chromosome Segregation
Centrosome Cycle
Centriole Replication
Brain Development
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Neurogenesis
Microtubule Organizing Center Organization
Positive Regulation Of Microtubule Polymerization
Regulation Of Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Centriole Replication
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Ciliary Basal Body-plasma Membrane Docking
Ganglioside Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Sphingomyelin Metabolic Process
Glycosphingolipid Metabolic Process
Lipid Transport
Locomotory Behavior
Regulation Of Cholesterol Esterification
Central Nervous System Myelin Formation
Regulation Of Intracellular Cholesterol Transport
Negative Regulation Of Intracellular Cholesterol Transport
Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Response To Drug
Cholesterol Homeostasis
Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process
Regulation Of Cholesterol Biosynthetic Process
Sphingosine Biosynthetic Process
Response To Steroid Hormone
Regulation Of Endopeptidase Activity
Transmembrane Transport
Regulation Of Protein Glycosylation
Response To Cholesterol
Negative Regulation Of Phospholipid Biosynthetic Process
Negative Regulation Of Sphingolipid Biosynthetic Process
Cellular Sphingolipid Homeostasis
Negative Regulation Of Cholesterol Efflux
Ceramide Translocation
Transport Across Blood-brain Barrier
Negative Regulation Of Cholesterol Esterification
Regulation Of Post-translational Protein Modification
Positive Regulation Of Amyloid-beta Formation
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Regulation Of Protein Localization To Cell Periphery
Negative Regulation Of Low-density Lipoprotein Receptor Activity
Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Regulation Of Protein Localization To Cell Surface
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
ABC transporters in lipid homeostasis
Drugs
Diseases
Primary microcephaly (MCPH)
GWAS
Asthma (
27611488
)
Height (
28552196
)
Photic sneeze reflex (
27182965
)
Response to statin therapy (
20339536
)
Rheumatoid arthritis (
24782177
)
Adverse response to drug (
30420678
)
White blood cell count (
32888494
)
Interacting Genes
25 interacting genes:
ABCA2
CDK5
CDK5R1
CLIP4
CRMP1
EEF1G
ERG28
FBXO25
HAP1
KAT5
LUC7L2
MAGEH1
MAPRE1
NEFL
PCBD1
PTN
RBM48
REPS2
SENP2
STARD9
STK36
TBC1D4
TRIM37
TSNAX
ZPR1
4 interacting genes:
CACNA1A
CDK5RAP2
DRD2
HTR6
Entrez ID
55755
20
HPRD ID
09740
08967
Ensembl ID
ENSG00000136861
ENSG00000107331
Uniprot IDs
A0A0A0MRG9
B3KVI2
B9EG74
Q7Z3M0
Q96SN8
Q9BZC7
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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