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CDK5RAP2 and NEFL
Data Source:
HPRD
(two hybrid)
CDK5RAP2
NEFL
Description
CDK5 regulatory subunit associated protein 2
neurofilament light
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Pericentriolar Material
Spindle Pole
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Microtubule
Gamma-tubulin Ring Complex
Cell Junction
Microtubule Plus-end
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Mitotic Spindle Pole
Cytoplasm
Cytosol
Neurofilament
Axon
Growth Cone
Neuromuscular Junction
Schaffer Collateral - CA1 Synapse
Cholinergic Synapse
Postsynaptic Intermediate Filament Cytoskeleton
Presynaptic Intermediate Filament Cytoskeleton
Axon Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
Protein Binding
Calmodulin Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Gamma-tubulin Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Phospholipase Binding
Protein-containing Complex Binding
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Establishment Of Mitotic Spindle Orientation
Microtubule Cytoskeleton Organization
Microtubule Bundle Formation
Chromosome Segregation
Centrosome Cycle
Centriole Replication
Brain Development
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Neurogenesis
Microtubule Organizing Center Organization
Positive Regulation Of Microtubule Polymerization
Regulation Of Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Centriole Replication
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Ciliary Basal Body-plasma Membrane Docking
MAPK Cascade
Microtubule Cytoskeleton Organization
Anterograde Axonal Transport
Retrograde Axonal Transport
Response To Toxic Substance
Peripheral Nervous System Axon Regeneration
Axonal Transport Of Mitochondrion
Spinal Cord Development
Hippocampus Development
Cerebral Cortex Development
Regulation Of Axon Diameter
Neurofilament Bundle Assembly
Locomotion
Response To Peptide Hormone
Negative Regulation Of Neuron Apoptotic Process
Intermediate Filament Polymerization Or Depolymerization
Intermediate Filament Organization
Neuron Projection Morphogenesis
Positive Regulation Of Axonogenesis
Neuromuscular Process Controlling Balance
Protein Polymerization
Response To Corticosterone
Neurofilament Cytoskeleton Organization
Synapse Maturation
Postsynaptic Intermediate Filament Cytoskeleton Organization
Response To Sodium Arsenite
Response To Acrylamide
Regulation Of NMDA Receptor Activity
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Diseases
Primary microcephaly (MCPH)
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Asthma (
27611488
)
Height (
28552196
)
Photic sneeze reflex (
27182965
)
Response to statin therapy (
20339536
)
Rheumatoid arthritis (
24782177
)
Fear of minor pain (
28701861
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) (
24554482
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) (
24554482
)
Interacting Genes
25 interacting genes:
ABCA2
CDK5
CDK5R1
CLIP4
CRMP1
EEF1G
ERG28
FBXO25
HAP1
KAT5
LUC7L2
MAGEH1
MAPRE1
NEFL
PCBD1
PTN
RBM48
REPS2
SENP2
STARD9
STK36
TBC1D4
TRIM37
TSNAX
ZPR1
50 interacting genes:
BRD7
CCDC13
CCDC172
CCDC33
CCNC
CDK5RAP2
CEP57L1
CHD3
DES
ENKD1
GFAP
GOLGA2
GORASP1
GRIN1
HGS
KDM1A
KIFC3
KLC3
KRT13
KRT15
KRT18
MAP2
MTMR2
MTUS2
MYO15B
MYO5A
NDN
NEFH
NEFM
NEK6
NME7
PDE4DIP
PIAS4
PKN1
PPP1R16B
PPP1R18
PRMT6
SKIL
SMYD1
SPTAN1
TERF1
TEX11
TRIM55
TRIM63
TSC1
TXLNB
USHBP1
USP2
VIM
YWHAG
Entrez ID
55755
4747
HPRD ID
09740
01206
Ensembl ID
ENSG00000136861
ENSG00000277586
Uniprot IDs
A0A0A0MRG9
B3KVI2
B9EG74
Q7Z3M0
Q96SN8
P07196
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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