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CDK5RAP2 and CDK5R1
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
CDK5RAP2
CDK5R1
Description
CDK5 regulatory subunit associated protein 2
cyclin dependent kinase 5 regulatory subunit 1
Image
No pdb structure
GO Annotations
Cellular Component
Pericentriolar Material
Spindle Pole
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Microtubule
Gamma-tubulin Ring Complex
Cell Junction
Microtubule Plus-end
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Mitotic Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Perikaryon
Intracellular Membrane-bounded Organelle
Contractile Fiber
Perinuclear Region Of Cytoplasm
Presynapse
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
Protein Binding
Calmodulin Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Gamma-tubulin Binding
Protease Binding
Protein Kinase Activity
Calcium Ion Binding
Protein Binding
Kinase Activity
Protein Kinase Binding
Protein Kinase Activator Activity
Ionotropic Glutamate Receptor Binding
Alpha-tubulin Binding
Protein Serine/threonine Kinase Activator Activity
Cadherin Binding
Ephrin Receptor Binding
Beta-tubulin Binding
Actin Filament Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Establishment Of Mitotic Spindle Orientation
Microtubule Cytoskeleton Organization
Microtubule Bundle Formation
Chromosome Segregation
Centrosome Cycle
Centriole Replication
Brain Development
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Neurogenesis
Microtubule Organizing Center Organization
Positive Regulation Of Microtubule Polymerization
Regulation Of Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Centriole Replication
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Ciliary Basal Body-plasma Membrane Docking
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Microtubule Cytoskeleton Organization
Neuron Migration
Neuron Cell-cell Adhesion
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Axon Guidance
Axonal Fasciculation
Brain Development
Embryo Development Ending In Birth Or Egg Hatching
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cerebellum Development
Superior Olivary Nucleus Maturation
Hippocampus Development
Layer Formation In Cerebral Cortex
Neuron Differentiation
Negative Regulation Of Axon Extension
Positive Regulation Of Microtubule Polymerization
Neuron Projection Development
Activation Of Protein Kinase Activity
Regulation Of Actin Cytoskeleton Organization
Ionotropic Glutamate Receptor Signaling Pathway
Serine Phosphorylation Of STAT Protein
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Neuron Differentiation
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Ephrin Receptor Signaling Pathway
Rhythmic Process
Regulation Of Dendritic Spine Morphogenesis
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Synaptic Vesicle Cycle
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
Drugs
Indirubin-3'-monoxime
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
Primary microcephaly (MCPH)
GWAS
Asthma (
27611488
)
Height (
28552196
)
Photic sneeze reflex (
27182965
)
Response to statin therapy (
20339536
)
Rheumatoid arthritis (
24782177
)
Interacting Genes
25 interacting genes:
ABCA2
CDK5
CDK5R1
CLIP4
CRMP1
EEF1G
ERG28
FBXO25
HAP1
KAT5
LUC7L2
MAGEH1
MAPRE1
NEFL
PCBD1
PTN
RBM48
REPS2
SENP2
STARD9
STK36
TBC1D4
TRIM37
TSNAX
ZPR1
31 interacting genes:
ACTN1
AMPH
APP
BLOC1S6
CAMK2A
CAPN1
CAPN2
CDK16
CDK5
CDK5RAP1
CDK5RAP2
CDK5RAP3
CDK9
CHN1
CTNNB1
HSP90AA1
KRT40
KRTAP10-3
LMTK2
MTUS2
NEDD4
NES
NOTCH2NLA
ODF1
PAK1
SEPTIN5
SET
SIAH1
STXBP1
TSC22D4
TTBK1
Entrez ID
55755
8851
HPRD ID
09740
04586
Ensembl ID
ENSG00000136861
ENSG00000176749
Uniprot IDs
A0A0A0MRG9
B3KVI2
B9EG74
Q7Z3M0
Q96SN8
Q15078
Q8N619
PDB IDs
1H4L
1UNG
1UNH
1UNL
3O0G
6LDP
7CNG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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