ABCA2 and HTR6

Data Source:
BioGRID (two hybrid)

		ABCA2	HTR6
Description		ATP binding cassette subfamily A member 2	5-hydroxytryptamine receptor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Microtubule Organizing Center Plasma Membrane Endosome Membrane Membrane Integral Component Of Membrane Cytoplasmic Vesicle ATP-binding Cassette (ABC) Transporter Complex Intracellular Membrane-bounded Organelle	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse
	Molecular Function	Nucleotide Binding Lipid Transporter Activity ATP Binding ATPase Activity ATPase-coupled Transmembrane Transporter Activity Endopeptidase Regulator Activity Ceramide Floppase Activity	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity
	Biological Process	Ganglioside Metabolic Process Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Sphingomyelin Metabolic Process Glycosphingolipid Metabolic Process Lipid Transport Locomotory Behavior Regulation Of Cholesterol Esterification Central Nervous System Myelin Formation Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Intracellular Cholesterol Transport Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Drug Cholesterol Homeostasis Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Sphingosine Biosynthetic Process Response To Steroid Hormone Regulation Of Endopeptidase Activity Transmembrane Transport Regulation Of Protein Glycosylation Response To Cholesterol Negative Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Cholesterol Efflux Ceramide Translocation Transport Across Blood-brain Barrier Negative Regulation Of Cholesterol Esterification Regulation Of Post-translational Protein Modification Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Low-density Lipoprotein Receptor Activity Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Protein Localization To Cell Surface	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		ABC transporters in lipid homeostasis	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Adverse response to drug ( 30420678) White blood cell count ( 32888494)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		4 interacting genes: CACNA1A CDK5RAP2 DRD2 HTR6	31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		20	3362
HPRD ID		08967	03066
Ensembl ID		ENSG00000107331	ENSG00000158748
Uniprot IDs		Q9BZC7	P50406
PDB IDs
Enriched GO Terms of Interacting Partners?
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