KRT2 and EVPL

Data Source:
HPRD (in vivo)

		KRT2	EVPL
Description		keratin 2	envoplakin
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleus Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Cornified Envelope Cytoplasm Cytosol Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Skin Epidermis	Structural Molecule Activity Intermediate Filament Binding Cadherin Binding
	Biological Process	Keratinocyte Development Epidermis Development Peptide Cross-linking Keratinization Keratinocyte Activation Keratinocyte Proliferation Intermediate Filament Organization Positive Regulation Of Epidermis Development Keratinocyte Migration Cornification	Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Wound Healing Intermediate Filament Cytoskeleton Organization Cornification
Pathways		Keratinization Formation of the cornified envelope	Formation of the cornified envelope
Drugs		Zinc Copper Anthralin Zinc acetate
Diseases		Ichthyosis bullosa of Siemens
GWAS			Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		15 interacting genes: EVPL KRT13 KRT15 KRT16 KRT19 KRT25 KRT27 KRT31 KRT33B KRT35 KRT36 KRT38 KRT40 SIRPA SMAD3	14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3
Entrez ID		3849	2125
HPRD ID		02560	03352
Ensembl ID		ENSG00000172867	ENSG00000167880
Uniprot IDs		P35908	B7ZLH8 K7EKI0 Q92817
PDB IDs			4QMD
Enriched GO Terms of Interacting Partners?
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