EVPL and PLEKHA5

Data Source:
BioGRID (two hybrid)

		EVPL	PLEKHA5
Description		envoplakin	pleckstrin homology domain containing A5
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GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome	Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Structural Molecule Activity Intermediate Filament Binding Cadherin Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Wound Healing Intermediate Filament Cytoskeleton Organization Cornification	Biological_process Reproductive System Development
Pathways		Formation of the cornified envelope	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)	Adult body size ( 32376654) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)
Interacting Genes		14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3	31 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SOGA1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		2125	54477
HPRD ID		03352	09684
Ensembl ID		ENSG00000167880	ENSG00000052126
Uniprot IDs		B7ZLH8 K7EKI0 Q92817	A0A024RAY7 Q9HAU0
PDB IDs		4QMD	2DKP
Enriched GO Terms of Interacting Partners?
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