EVPL and CSTA

Data Source:
HPRD (in vivo)

		EVPL	CSTA
Description		envoplakin	cystatin A
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GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Structural Molecule Activity Intermediate Filament Binding Cadherin Binding	Protease Binding Cysteine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Wound Healing Intermediate Filament Cytoskeleton Organization Cornification	Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cornification Cell-cell Adhesion
Pathways		Formation of the cornified envelope	Formation of the cornified envelope
Drugs
Diseases
GWAS		Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)	Apolipoprotein B levels ( 32203549) Calcium levels ( 25972035 29403010 20705733)
Interacting Genes		14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3	12 interacting genes: CTSB CTSH CTSL DSP EVPL IVL KRT1 LORICRIN PI3 PTN UCHL5 ZDHHC17
Entrez ID		2125	1475
HPRD ID		03352	01697
Ensembl ID		ENSG00000167880	ENSG00000121552
Uniprot IDs		B7ZLH8 K7EKI0 Q92817	P01040
PDB IDs		4QMD	1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE
Enriched GO Terms of Interacting Partners?
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